Results 31 to 40 of about 68,113 (243)
Regulation of complement-dependent cytotoxicity by TGF-β-induced epithelial-mesenchymal transition. [PDF]
Oncogene, 2016 The process of epithelial-mesenchymal transition (EMT), in addition to being an initiating event for tumor metastasis, is implicated in conferring several clinically relevant properties to disseminating cancer cells. These include stem cell-like properties, resistance to targeted therapies and ability to evade immune surveillance.
Goswami MT +6 more
europepmc +4 more sources
Complement-dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies [PDF]
British Journal of Cancer, 1982 Two mouse monoclonal antibodies against the human osteogenic sarcoma 791T were examined for their capacity to exert complement-dependent cytotoxicity against a panel of human tumour cell lines. Cytotoxicity was most evident against the immunizing tumour 791T although significant reactivity was directed against other osteogenic sarcomas.
Price, M R, Pimm, M V, Baldwin, R W
openaire +2 more sources
Biomedicines, 2021 Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via complement-dependent cytotoxicity (CDC).
Carolin Schmidt +8 more
doaj +1 more source
Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity [PDF]
Journal of Histochemistry & Cytochemistry, 2013 Passive immunity of the nervous system has traditionally been thought to be predominantly due to the blood-brain barrier. This concept must now be revisited based on the existence of neuron-derived IgG. The conventional concept is that IgG is produced solely by mature B lymphocytes, but it has now been found to be synthesized by murine and human ...
Jie, Zhang +3 more
openaire +2 more sources
Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma
Cells, 2020 Daratumumab (Dara) is the first-in-class human-specific anti-CD38 mAb approved for the treatment of multiple myeloma (MM). Although recent data have demonstrated very promising results in clinical practice and trials, some patients do not achieve a ...
Ilaria Saltarella +9 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
PLoS Biology, 2016 IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing.
Rob N de Jong +12 more
doaj +1 more source
Frontiers in Immunology, 2019 The interactions of cancer cells with components of the complement system are highly complex, leading to an outcome that is either favorable or detrimental to cancer cells. Currently, we perceive only the “tip of the iceberg” of these interactions.
Zvi Fishelson, Michael Kirschfink
doaj +1 more source
How Does Complement Affect Hematological Malignancies: From Basic Mechanisms to Clinical Application
Frontiers in Immunology, 2020 Complement, as a central immune surveillance system, can be activated within seconds upon stimulation, thereby displaying multiple immune effector functions.
Shanshan Luo +7 more
doaj +1 more source