Results 141 to 150 of about 844,522 (297)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy. [PDF]

Neurol Neuroimmunol Neuroinflamm
Stascheit F, Preßler H, Stein K, Pernice HF, Hahn K, Meisel A, Lünemann JD.   +6 more
europepmc   +1 more source

Clusterin: modulation of complement function [PDF]

, 1994
Jürg Tschopp, Lars E. French
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Expanding the Diagnostic Lens: Mast Cell Activation Syndromes and the Hidden Spectrum of Angioedema Associated Mortality in COVID-19. [PDF]

Acad Forensic Pathol
Sison EL, Aban JL.
europepmc   +2 more sources

The contribution of the membrane-bound complement regulatory proteins CD46 and CD55 in phases of acute lymphocytic leukemia and acute myelogenous leukemia. [PDF]

Sci Rep
Onsi LA, Ammar P, Abdelaziz H, Abou-Aisha K, Farag N, El-Azizi M.   +5 more
europepmc   +1 more source

Analyzing the relationship of Leishmania chagasi and complement resistance through protein-protein interactions, genetic complementation, and innovative techniques

, 2009
Eric J. Scolaro
openalex   +2 more sources

Isolating the Epstein-Barr Virus gp350/220 Binding Site on Complement Receptor Type 2 (CR2/CD21) [PDF]

, 2007
Kendra A. Young, Xiaojiang S. Chen, V. Michael Holers, Jonathan P. Hannan   +3 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Case Report: Possible C3 nephritic factor-driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with <i>Bordetella parapertussis</i> infection. [PDF]

Front Immunol
Thorsen SU, Hansen AT, Hartling HJ, Marquart HV, Borgwardt L, Laustsen MM, Skattum L, Nielsen ACY, Sehested LT, Nørgaard H, Dziegiel MH, Schmidt IM.   +11 more
europepmc   +1 more source