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Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism
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Complement and Complement Deficiencies
Seminars in Liver Disease, 1997The complement system provides a first line of defense and mediates a large variety of cellular and humoral interactions within the immune response, including chemotaxis, phagocytosis, cell adhesion, and B-cell differentiation. The system involves more than 30 serum components and numerous cell surface regulators and receptors.
Keith Whaley, Wilhelm J. Schwaeble
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Microglia mediate forgetting via complement-dependent synaptic elimination
Science, 2020Microglia modulate memories Synaptic reorganization and circuit rewiring leads to loss or weakening of connections between neurons and may result in the erasure of previously formed memories. Microglia eliminate excessive synapses in the developing brain
Chao Wang +11 more
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Arthritis & Rheumatology, 2023
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis.
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The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis.
openaire +2 more sources
Southern Medical Journal, 1979
Publisher Summary The name complement was given to describe the heat-labile property of normal human serum that “complements” the action of antibody in producing the immune lysis of red blood cells and bacteria. It soon became apparent that complement was highly complex biochemically and functionally.
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Publisher Summary The name complement was given to describe the heat-labile property of normal human serum that “complements” the action of antibody in producing the immune lysis of red blood cells and bacteria. It soon became apparent that complement was highly complex biochemically and functionally.
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2013
In this chapter we summarize clinically important aspects of complement biology. This information is used to present a comprehensive overview of complement deficiency states and provide a logical basis for understanding complement assays in clinical practice.
Matthew C. Pickering, Jyoti Bakshi
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In this chapter we summarize clinically important aspects of complement biology. This information is used to present a comprehensive overview of complement deficiency states and provide a logical basis for understanding complement assays in clinical practice.
Matthew C. Pickering, Jyoti Bakshi
openaire +1 more source