Results 1 to 10 of about 3,430 (122)

C1-inactivator is upregulated in glioblastoma. [PDF]

PLoS One, 2017
Background Glioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body’s immune response.
Förnvik K, Maddahi A, Persson O, Osther K, Salford LG, Nittby Redebrandt H.   +5 more
europepmc   +2 more sources

Quantification of human C1 esterase inhibitor protein using an automated turbidimetric immunoassay. [PDF]

J Clin Lab Anal, 2019
BACKGROUND: Impaired levels or function of C1 inhibitor (C1-INH) results in angioedema due to increased bradykinin. It is important to distinguish between angioedema related to C1-INH deficiency and that caused by other mechanisms, as treatment options ...
Tange CE, Kaur A, Verma N, Hickey A, Grigoriadou S, Scott C, Kiani S, Steven R, Ponsford M, El-Shanawany T, Jolles S, Harding S, Parker AR.   +12 more
europepmc   +4 more sources

A Case Report about the Management of Hereditary Angioedema with Normal Complement Levels during Pregnancy

Acta Médica Portuguesa, 2023
N/a. 
Ana Raquel Pinto, Inês Machado Cunha, Fabrícia Carolino   +2 more
doaj   +1 more source

Active disassembly of the first complement component, C-1, by C-1 inactivator.

Journal of Immunology, 1979
In order to clarify its mechanism of disassembly, the first component of human complement, C1, was reconstituted from C1q, 125I-C1r, and 131I-C1s. This radiolabeled C1 bound tightly to aggregated IgG covalently linked to Sepharose 4B.
R. Ziccardi, Neil R. Cooper
semanticscholar   +1 more source

No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice

Vascular Biology, 2022
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture.
S. Hibender, Siyu Li, A. Postma, Myrthe E Hoogeland, D. Klaver, R. Pouw, H. Niessen, Antoine H. G. Driessen, D. Koolbergen, C. D. de Vries, M. Baars, A. Houweling, P. Krijnen, V. de Waard   +13 more
semanticscholar   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +3 more sources

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2013
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H, Galanakis, DK, Ghebrehiwet, B, Hosszu, KH, Ji, Y, Kew, RR, Kishore, U, Pednekar, L, Peerschke, EIB, Ramadass, M, Valentino, A   +10 more
core   +2 more sources

Quantification of human complement C2 protein using an automated turbidimetric immunoassay [PDF]

, 2018
Background: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease.
Brohet, Fabian, Cook, Alex, El-Shanawany, Tariq, Harding, Stephen, Johnson-Brett, Bridget, Jolles, Stephen, Parker, Antony Richard, Ponsford, Mark, Roberts, Andrew, Steven, Rachel, Stordeur, Patrick, Tange, Clare Elizabeth, Wallis, Gregg   +12 more
core   +2 more sources

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Junjie Chen, B. H. D. Teo, Seng Yin Kelly Wee, M. Wong, Jianzhou Cui, Jinmiao Chen, K. Leong, Jinhua Lu   +8 more
semanticscholar   +1 more source

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
Background Dysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, K. Fromell, C. Scavenius, L. Vogt, Ewa Bielecka, J. Potempa, J. Enghild, B. Nilsson, K. Ekdahl, M. Kapetanovic, Anna M. Blom   +12 more
semanticscholar   +1 more source