Results 21 to 30 of about 2,032,664 (124)

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease

Cardiology Research and Practice, Volume 2012, Issue 1, 2012., 2012
Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll‐like receptors (TLRs) of the innate immune system. As sentinels of innate immunity TLRs are nonclonally germline‐encoded molecular pattern recognition receptors that recognize exogenous as well as tissue‐derived ...
Rolf Spirig, Janice Tsui, Sidney Shaw, Daryll M. Baker   +3 more
wiley   +1 more source

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley   +1 more source

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement [PDF]

, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Matthew L Rotondi, Trevor P Creamer, Henry A. Choy, Brissette Catherine A., Kraiczy Peter, DeMoll, Edward, Edward Demoll, Peter Kraiczy, Stevenson, Brian, Suchard, Marc A, Creamer, Trevor P., Cooley Anne E., Matthew L. Rotondi, Kraiczy, Peter, Suchard, Marc A., Marc A. Suchard, Haake David A., Marija Pinne, Brissette, Catherine A, Catherine A. Brissette, Cooley, Anne E., Marc A Suchard, DeMoll Edward, Creamer, Trevor P, Pinne Marija, Verma, Ashutosh, Miller M. Clarke, Choy Henry A., Miller, M. Clarke, M Clarke Miller, Choy, Henry A, Pinne, Marija, Catherine A Brissette, Trevor P. Creamer, Verma Ashutosh, Haake, David A, Anne E. Cooley, Brissette, Catherine A., Rotondi, Matthew L., Suchard Marc A., Stevenson Brian, Creamer Trevor P., Brian Stevenson, Ashutosh Verma, M. Clarke Miller, Miller, M Clarke, Rotondi, Matthew L, Haake, David A., Rotondi Matthew L., Henry A Choy, David A Haake, Cooley, Anne E, Choy, Henry A., Anne E Cooley, David A. Haake   +54 more
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Inhibitors of Complement Activity in Human Breast‐Milk: A Proposed Hypothesis of Their Physiological Significance

Mediators of Inflammation, Volume 8, Issue 2, Page 69-75, 1999., 1999
Several natural components abundant in the fluid phase of human breast‐milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement ...
Michael Oladipo Ogundele
wiley   +1 more source

Biochemical and functional studies on mouse ficolin-B, a novel pattern recognition molecule of the innate immune system [PDF]

, 2011
Ficolins are members of the collectin family of proteins which in human and mice are able to recognize pathogen associated molecular patterns (PAMPs) on microbial surfaces.
Elumalai, Preetham
core   +1 more source

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2014
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
Ramadass, M, Kishore, U, Ji, Y, Pednekar, L, Peerschke, EIB, Ghebrehiwet, B, David, H, Galanakis, DK, Valentino, A, Kew, RR, Hosszu, KH   +10 more
core   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

The Role of Complement in Cancer Immunotherapy [PDF]

, 2022
The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...

core   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
core   +1 more source