Effects of weak anchoring on C1 and C2 chevron structures [PDF]
, 2005 We present a theoretical study of the effect of weak anchoring on the transition between C1 and C2 chevron structures in smectic C liquid crystals. We employ a continuum theory which allows for variable cone, azimuthal and layer tilt angles.
Mottram, Nigel +2 more
core +5 more sources
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings [PDF]
, 2011 Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or ...
Maciejewski, Mateusz +5 more
core +1 more source
Self-association of complement factor H in the presence and absence of metals [PDF]
, 2010 In the complement system of innate immunity, factor H (FH) is a major regulator of its activation, and is comprised of 20 short complement regulator (SCR) domains.
Nan, R.
core
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions [PDF]
, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Kishore, U +3 more
core +1 more source
The Role of Complement in Tumors
, 2020 The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.
core +1 more source
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis +11 more
core +1 more source
Identification of defensin binding to C1 complement [PDF]
, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C1) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer (r2s2) and C1i did not bind defensin. When (r2s2) was dissociated by EDTA, only the activated C1s
Yiou Tseng +9 more
core +1 more source
The role of complement in synaptic degeneration
, 2012 Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core +1 more source
The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]
, 2010 The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core
A Newly Described Control Mechanism of Complement Activation in Patients with Mixed Cryoglobulinemia (Cryoglobulins and Complement) [PDF]
, 1980 Levels in serum of components of complement were studied in a group of 10 patients with mixed cryoglobulinemia. The profiles found in most patients showed decreased levels of the early complement components C1, C4, and C2, with normal levels of C3 ...
de Rojas, Marta Patarroyo +2 more
core +1 more source