Results 11 to 20 of about 1,359 (119)

Complement System Part I – Molecular Mechanisms of Activation and Regulation [PDF]

, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Lubka T. Roumenina, Nicolas S. Merle, Sarah Elizabeth Church, Veronique Fremeaux-Bacchi   +3 more
core   +16 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
A Alitalo, A Alitalo, A Alitalo, A Seling, AC Steere, AM Blom, Andreas Klos, AP van Dam, B Stevenson, C Hammerschmidt, C Siegel, C Siegel, Christine Skerka, Claudia Hammerschmidt, CS Brooks, Dania Richter, E Diza, F Strle, Franz-Rainer Matuschka, H Jiang, H Michel, J Hellwage, J Pietikainen, J Potempa, Jasmin Schwab, JD Lambris, JV McDowell, K Hartmann, K Haupt, K Kurtenbach, K Kurtenbach, K Saito, K Whaley, KM Hovis, KP Hunfeld, L Beinrohr, M Collares-Pereira, M Jusko, M Józsi, MJ Walport, MK Pangburn, MR Bhide, MR Bhide, MR Kenedy, MS Metts, N Marr, ND van Burgel, P Herzberger, P Herzberger, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Ramu, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, R Dieterich, R Wallich, Reinhard Wallich, RG Discipio, RJ Ziccardi, S Breitner-Ruddock, S Grosskinsky, S Grosskinsky, S Heinen, S Kühn, SC Bock, SG Rijpkema, SH Rooijakkers, T Fujita, T Fujita, V Brade, Y Terao   +76 more
core   +7 more sources

Quantification of human complement C2 protein using an automated turbidimetric immunoassay [PDF]

, 2018
Background: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease.
Brohet, Fabian, Cook, Alex, El-Shanawany, Tariq, Harding, Stephen, Johnson-Brett, Bridget, Jolles, Stephen, Parker, Antony Richard, Ponsford, Mark, Roberts, Andrew, Steven, Rachel, Stordeur, Patrick, Tange, Clare Elizabeth, Wallis, Gregg   +12 more
core   +2 more sources

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2013
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H, Galanakis, DK, Ghebrehiwet, B, Hosszu, KH, Ji, Y, Kew, RR, Kishore, U, Pednekar, L, Peerschke, EIB, Ramadass, M, Valentino, A   +10 more
core   +2 more sources

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma. [PDF]

Front Immunol, 2020
Copyright © 2020 DeCordova, Shastri, Tsolaki, Yasmin, Klein, Singh and Kishore. Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor prognosis, despite surgical resection combined with radio- and chemotherapy.
DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, Kishore U.   +6 more
europepmc   +3 more sources

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
core   +1 more source

Inactivation of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath) by acetylene [PDF]

, 2015
Acetylene (HCCH) has a long history as a mechanism-based enzyme inhibitor and is considered an active-site probe of the particulate methane monooxygenase (pMMO).
Chan, Sunney I., Chang, Brian T.-A., Chen, Chein-Hung, Chen, Chung-Hsuan, Han, Chau-Chung, Li, Mai Suan, Lin, Ya-Ping, Nagababu, Penumaka, Ng, Kok Yaoh, Pham, Minh D., Vuong, Quan Van, Yu, Steve S.-F.   +11 more
core   +1 more source

Effect of lipopolysaccharide on C3 and C5 production by human lung cells [PDF]

, 1989
Although studies to date have demonstrated the ability of the monocyte/macrophage to produce C components in vitro, very few studies on C production by nonhepatic tissue cells have been reported.
Despins, Alan, Kennedy, Thomas, Kreutzer, Donald L., Merrow, Martha, Rothman, Barbara L.   +4 more
core   +6 more sources

Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series

Case Reports in Pediatrics, Volume 2024, Issue 1, 2024.
Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn’s disease and sarcoidosis, and an accurate diagnosis
Taku Kimura, Ken-Ichiro Sakata, Shunichiro Takezaki, Takuya Asaka, Shohei Oshima, Aya Yanagawa-Matsuda, Yoshimasa Kitagawa, Paul A. Rufo   +7 more
wiley   +1 more source