Results 11 to 20 of about 2,032,664 (124)

The role of complement in the clinical course of hepatocellular carcinoma

Immunity, Inflammation and Disease, Volume 10, Issue 3, March 2022., 2022
C1R, C6, C7, CFP, and CFHR3 could be prognostic biomarkers for patients with HCC. Based on that, we developed a prognostic model for HCC patients—Riskscore = (−0.0053)*C6+(−0.0498)*C7+(−0.1045)*CFHR3. Abstract Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in
Xinye Qian, Zhoujing Yang, Lu Gao, Yipiao Liu, Jun Yan   +4 more
wiley   +1 more source

Luteal expression of factors involved in the metabolism and sensitivity to oestrogens in the dog during pregnancy and in non‐pregnant cycle

Reproduction in Domestic Animals, Volume 57, Issue 1, Page 86-97, January 2022., 2022
Abstract The canine corpus luteum (CL) is the main source of reproductive steroids during dioestrus in the dog and remains active even in the absence of pregnancy (non‐pregnant dioestrus, physiological pseudopregnancy). Whereas the biological effects of 17β‐oestradiol (E2) in the canine CL remain unclear, the transcriptional availability of oestrogen ...
Miguel Tavares Pereira, Paula Papa, Iris Margaret Reichler, Selim Aslan, Mariusz Pawel Kowalewski   +4 more
wiley   +1 more source

Mast cells and complement system: Ancient interactions between components of innate immunity

Allergy, Volume 75, Issue 11, Page 2818-2828, November 2020., 2020
Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules.
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Petri T. Kovanen, Seppo Meri   +3 more
wiley   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Schmid, Ralf, Schwaeble, Wilhelm J., Wilhelm J. Schwaeble, Anthony H. Keeble, Russell Wallis, Mitchell, Daniel A., Keeble, Anthony H., Wallis, Russell, Ralf Schmid, Daniel A. Mitchell   +9 more
core   +1 more source

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
core   +1 more source

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi [PDF]

, 2010
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.
Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard   +34 more
core   +2 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +2 more sources