Results 11 to 20 of about 3,430 (122)

The role of complement in the clinical course of hepatocellular carcinoma

Immunity, Inflammation and Disease, Volume 10, Issue 3, March 2022., 2022
C1R, C6, C7, CFP, and CFHR3 could be prognostic biomarkers for patients with HCC. Based on that, we developed a prognostic model for HCC patients—Riskscore = (−0.0053)*C6+(−0.0498)*C7+(−0.1045)*CFHR3. Abstract Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in
Xinye Qian, Zhoujing Yang, Lu Gao, Yipiao Liu, Jun Yan   +4 more
wiley   +1 more source

Luteal expression of factors involved in the metabolism and sensitivity to oestrogens in the dog during pregnancy and in non‐pregnant cycle

Reproduction in Domestic Animals, Volume 57, Issue 1, Page 86-97, January 2022., 2022
Abstract The canine corpus luteum (CL) is the main source of reproductive steroids during dioestrus in the dog and remains active even in the absence of pregnancy (non‐pregnant dioestrus, physiological pseudopregnancy). Whereas the biological effects of 17β‐oestradiol (E2) in the canine CL remain unclear, the transcriptional availability of oestrogen ...
Miguel Tavares Pereira, Paula Papa, Iris Margaret Reichler, Selim Aslan, Mariusz Pawel Kowalewski   +4 more
wiley   +1 more source

Mast cells and complement system: Ancient interactions between components of innate immunity

Allergy, Volume 75, Issue 11, Page 2818-2828, November 2020., 2020
Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules.
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Petri T. Kovanen, Seppo Meri   +3 more
wiley   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
core   +1 more source

Complement activation in inflammatory skin diseases [PDF]

, 2018
The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating
Damman, J. (Jeffrey), Doorn, M.B.A. (Martijn) van, Giang, J. (Jenny), Prens, E.P. (Errol), Rissmann, R. (Robert), Seelen, M.A.J.   +5 more
core   +11 more sources

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis

International Journal of Molecular Sciences, 2022
Autoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury.
M. Radanova, V. Vasilev, G. Mihaylova, M. Kosturkova, U. Kishore, L. Roumenina   +5 more
semanticscholar   +1 more source

The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease

Cardiology Research and Practice, Volume 2012, Issue 1, 2012., 2012
Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll‐like receptors (TLRs) of the innate immune system. As sentinels of innate immunity TLRs are nonclonally germline‐encoded molecular pattern recognition receptors that recognize exogenous as well as tissue‐derived ...
Rolf Spirig, Janice Tsui, Sidney Shaw, Daryll M. Baker   +3 more
wiley   +1 more source

Quantitation of 55 Common Human Plasma Proteins in Healthy Young Adults and Correlation with Body Mass Index and Dietary Patterns [PDF]

, 2010
Plasma biomarkers are a useful tool for monitoring dietary exposures and the development of chronic disease. Measuring multiple biomarkers at once provides a more complete characterization of phenotype than measuring single markers.
Ahmed El-Sohemy, Alaa Badawi, Bibiana Garcia-Bailo, Bibiana Garcia-Bailo, Christoph Borchers, Daiva Nielsen, Darren Brenner, Hyeon-Joo Lee, Mohamed Karmali   +8 more
core   +2 more sources

Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley   +1 more source