Results 11 to 20 of about 2,240 (97)
The role of complement in the clinical course of hepatocellular carcinoma
Immunity, Inflammation and Disease, Volume 10, Issue 3, March 2022., 2022 C1R, C6, C7, CFP, and CFHR3 could be prognostic biomarkers for patients with HCC. Based on that, we developed a prognostic model for HCC patients—Riskscore = (−0.0053)*C6+(−0.0498)*C7+(−0.1045)*CFHR3. Abstract Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in
Xinye Qian +4 more
wiley +1 more source
Reproduction in Domestic Animals, Volume 57, Issue 1, Page 86-97, January 2022., 2022 Abstract The canine corpus luteum (CL) is the main source of reproductive steroids during dioestrus in the dog and remains active even in the absence of pregnancy (non‐pregnant dioestrus, physiological pseudopregnancy). Whereas the biological effects of 17β‐oestradiol (E2) in the canine CL remain unclear, the transcriptional availability of oestrogen ...
Miguel Tavares Pereira +4 more
wiley +1 more source
Mast cells and complement system: Ancient interactions between components of innate immunity
Allergy, Volume 75, Issue 11, Page 2818-2828, November 2020., 2020 Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules.
Daniel Elieh Ali Komi +3 more
wiley +1 more source
The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease
Cardiology Research and Practice, Volume 2012, Issue 1, 2012., 2012 Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll‐like receptors (TLRs) of the innate immune system. As sentinels of innate immunity TLRs are nonclonally germline‐encoded molecular pattern recognition receptors that recognize exogenous as well as tissue‐derived ...
Rolf Spirig +3 more
wiley +1 more source
Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia
Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012 Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and stoichiometry ...
Peter D. Gorevic, Domenico Sansonno
wiley +1 more source
Mediators of Inflammation, Volume 8, Issue 2, Page 69-75, 1999., 1999 Several natural components abundant in the fluid phase of human breast‐milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement ...
Michael Oladipo Ogundele
wiley +1 more source
Polyhalogenated Carbohydrates: Synthesis and Applications of Sugar Halides from Fluorine to Iodine
European Journal of Organic Chemistry, Volume 27, Issue 16, April 22, 2024.The societal importance of sucralose (a trichlorinated disaccharide) doesn't fade over time. This review focuses on the synthesis and applications of polyhalogenated carbohydrates incorporating fluorine, chlorine, bromine, and iodine atoms. An overview of the current state of the art of sugar inter‐halides is also presented.
Olivier Lessard +2 more
wiley +1 more source
Biomolecular Corona of Gold Nanoparticles: The Urgent Need for Strong Roots to Grow Strong Branches
Small, Volume 20, Issue 15, April 11, 2024.This review presents a critical analysis of the current methodologies to decipher bio‐nano interactions by analyzing the biomolecular corona using gold nanoparticles as a case study. The study aims for a collective effort of the nano‐community through standardization of methodologies (for synthesis, characterization, and omics), data sharing, and ...
Luca Boselli +4 more
wiley +1 more source
Case Reports in Pediatrics, Volume 2024, Issue 1, 2024.Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn’s disease and sarcoidosis, and an accurate diagnosis
Taku Kimura +7 more
wiley +1 more source
Anti-C1-inactivator treatment of glioblastoma
OncoTarget, 2018 Purpose Glioblastoma multiforme (GBM) or astrocytoma grade IV is the most common type of primary brain tumor in adults. In the present study, we investigate the role of the complement system in the glioblastoma situation in an experimental model, since ...
Karolina Förnvik +4 more
semanticscholar +1 more source