Results 151 to 160 of about 65,236 (304)

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Hydrophobic residues in the α‐synuclein NAC domain drive seed‐competent fibril formation and are targeted by peptide inhibitors

The FEBS Journal, EarlyView.
The hydrophobic 68GAVV71 stretch in the NAC domain of α‐synuclein is essential for nucleation, while residues 79–95 are required for fibril stability and seeding. Truncation or inhibition of 68GAVV71 prevents fibril formation, and truncation of 79–95 abolishes seeding competency, highlighting their distinct roles in α‐synuclein aggregation and ...
Viswanath Das, Sayed Mostafa Modarres Mousavi, Narendran Annadurai, Sunčica Sukur, Faramarz Mehrnejad, Sajad Moradi, Lukáš Malina, Markéta Kolaříková, Vaclav Ranc, Ivo Frydrych, Roman Kouřil, Saman Hosseinkhani, Marián Hajdúch, Maryam Nikkhah   +13 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Neuroprotection by Complement (C1) Inhibitor in Mouse Transient Brain Ischemia

Journal of Cerebral Blood Flow and Metabolism, 2003
M. D. Simoni, C. Storini, M. Barba, L. Catapano, A. Arabia, Emanuela Rossi, Luigi Bergamaschini   +6 more
semanticscholar   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients. [PDF]

Sci Rep
Kiszel P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z.   +5 more
europepmc   +1 more source

Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients.

Journal of Clinical Investigation, 1986
B. Zuraw, J. Curd
semanticscholar   +1 more source

Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL‐2 proteins

The FEBS Journal, EarlyView.
How the structure of HRK, a member of the BCL‐2 protein family, contributes to its function is poorly understood. Functional analysis of HRK mutants reveals that HRK induces apoptosis in a BH3‐domain‐dependent, but transmembrane‐domain‐independent, manner. The transmembrane domain localises HRK to mitochondria, but alone is insufficient.
Louise E. King, Lukas Faber, Ana J. García‐Sáez   +2 more
wiley   +1 more source

Acquired Angioedema Related to Transient C1- Inhibitor Deficiency Triggered by <i>Mycoplasma pneumoniae</i> Infection: A Case Report. [PDF]

Reports (MDPI)
Peristeri AM, Akritidou O, Nikopoulou A, Theodoridou K, Leontakianakos M, Theocharidou CC, Pilianidis G.   +6 more
europepmc   +1 more source

CLE19 suppresses brassinosteroid signaling output via the BSL‐BIN2 module to maintain BES1 activity and pollen exine patterning in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
Antagonistic crosstalk between the microspore‐derived CLE19 peptide and brassinosteroid signaling preserves pollen developmental homeostasis in Arabidopsis. CLE19 activates a protein phosphatase—kinase cascade to phosphorylate the transcription factor BES1, triggering its inactivation and suppressing brassinosteroid signaling outputs, thereby fine ...
Shuangshuang Wang, Shiting Zhang, Ying Yu, Jianzheng Wang, Jingya Wang, Mengyu Li, Jianan Lu, Juanying Ye, Hanji Li, Yeqiao Liu, Yuhan Zhao, Wen Song, Juan Dong, Jia Li, Chunming Liu, Hong Ma, Fang Chang   +16 more
wiley   +1 more source