Results 231 to 240 of about 49,543 (282)

Innate Immunity in the Pathogenesis of Selected Autoimmune Neurological Diseases. [PDF]

J Clin Med
Rudnicka-Czerwiec J, Bartosik-Psujek H.
europepmc   +1 more source

CRISPR-Cas9 gene editing for hereditary angioedema: current treatments and emerging therapies. [PDF]

Ann Med Surg (Lond)
Jalal L, Taimuri MA, Sumbal A, Ikram A, Ali T, Khan A, Alam S, Arama UO, Yokolo H.   +8 more
europepmc   +1 more source

Efficacy and acceptability of lanadelumab for long-term prophylaxis in hereditary angioedema: A Chinese multicenter real-world analysis. [PDF]

World Allergy Organ J
Xu Y, Ji R, Liu J, Cui X, Zhang H, Cao N, Yu Y, Li Y, Lai H, Zhi Y.   +9 more
europepmc   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Expanding the Genetic and Clinical Spectrum of Hereditary Angioedema with Normal C1 Inhibitor: Novel Variants and Treatment Insights. [PDF]

J Clin Immunol
Gao H, Zhao Y, Chen S, Zhang Z, Yang F, Chen Z, Wang L, Yang J, He S, Tang C, Zheng S, Guan C, Xu Y, Tang L, Zhang A, Maurer M, Lee D, Ma L, Luo X.   +18 more
europepmc   +1 more source

Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery

Advanced Functional Materials, Volume 36, Issue 3, 8 January 2026.
This study optimizes two methods for the generation of extracellular vesicle (EV)‐mimetic‐Lipid Nanoparticle (LNP) (CELLNPs) and EV‐LNP (HEVs) hybrid nanoparticles for messenger (mRNA) delivery. The authors screen lipid compositions to maximize hybrid nanoparticle formation and analyze the resulting nanoparticles with single particle characterization ...
Ana Filipa Louro, Inês Gomes, Chuan‐En Lu, Marco A. Alfonzo‐Méndez, Niek Dekker, Mohsin Khan, Elisa Lázaro‐Ibáñez   +6 more
wiley   +1 more source

Hereditary Angioedema Prophylaxis Therapy: Berotralstat and Lanadelumab Safety Profile. [PDF]

Medicina (Kaunas)
Donadoni M, La Cava L, Bizzi E, Popescu Janu V, Meschia A, Cirigliano F, Cogliati C, Gidaro A.   +7 more
europepmc   +1 more source

Metabolic subtyping reveals PDIK1L as a dual-functional regulator of progression and PARP inhibitor sensitivity in prostate cancer. [PDF]

Front Cell Dev Biol
Wang Z, Ge Q, Aihetaimujiang A, Zhang J, Lu J, Yang J, Chen Y, Qin B, Zhang H, Xu WH, Ye D.   +10 more
europepmc   +1 more source

Multiplexed Quantitation of Plasma Proteins by Targeted Mass Spectrometry for Early Diagnosis of Pancreatic Ductal Adenocarcinoma. [PDF]

Int J Mol Sci
Korobkov DN, Molodtsov IA, Kononikhin AS, Bugrova AE, Indeykina MI, Brzhozovskiy AG, Kanner DY, Nikolaev EN, Vasilieva E, Komissarov AA.   +9 more
europepmc   +1 more source