Results 51 to 60 of about 65,236 (304)

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

Frontiers in Immunology, 2018
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under ...
Mariana Gaya da Costa, Felix Poppelaars, Felix Poppelaars, Cees van Kooten, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Francesco Tedesco, Reinhard Würzner, Leendert A. Trouw, Leendert A. Trouw, Lennart Truedsson, Mohamed R. Daha, Mohamed R. Daha, Anja Roos, Marc A. Seelen   +15 more
doaj   +1 more source

Disturbances of protein c activity in abdominal sepsis: Diagnostic and predictive importance [PDF]

Vojnosanitetski Pregled, 2004
Background. Despite improved diagnostic modalities, potent antibiotics, modern intensive care, and aggressive surgical treatment, more than one third of patients still die of severe secondary peritonitis.
Karamarković Aleksandar P., Mirković Darko, Stanković Nebojša, Nikolić Valentina, Jeremić Vasilije, Radenković Dejan, Stefanović Branislav   +6 more
doaj   +1 more source

Delving into Vertebrate Serpins for Understanding their Evolution [PDF]

, 2009
The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
core   +2 more sources

Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin. [PDF]

PLoS ONE, 2015
Affinity purification, immunoprecipitation, gel electrophoresis and mass spectrometry were used to identify fibulin-1C, C1 esterase inhibitor and glucose regulated protein 75, grp75, as binding partners of the CREC proteins, calumenin and reticulocalbin.
Gry Aune Westergaard Hansen, Maja Ludvigsen, Christian Jacobsen, Claudia Cangemi, Lars Melholt Rasmussen, Henrik Vorum, Bent Honoré   +6 more
doaj   +1 more source

Treatment of hereditary angioedema—single or multiple pathways to the rescue

Frontiers in Allergy, 2022
Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
Anna Valerieva, Hilary J. Longhurst
doaj   +1 more source

Enzimreakciók vizsgálata a moduláris szerveződés, az atomi kölcsönhatás és a kvantummechanika szintjein. A fehérje biofizika tudományos iskolája = Insight into the Enzyme Action at Levels of modular Organization, Atomic Interactions and Quantum-Mechanics. School of Protein Biophysics [PDF]

, 2009
Az elmúlt 3 év koherens kutató munkája során születtek speciális tudományos eredmények és levontunk ezekből általános következtetéseket is. Munkánk mérlege a nemzetközi folyóiratokban megjelent 30 közlemény összesen 130 IF-al. Molekuláris immunológiai
Barna, László, Beinrohr, László, Borbola, Ildikó, Cseh-Szilágyi, Katalin, Dobó, József, Gyimesi, Gergely, Gál, Péter, Hajdú, István, Juhász, Tünde, Kamondi, Szilárd, Kazinczyné Vas, Mária, Kocsis, Andrea, Major, Balázs, Pollnerné Flachner, Beáta, Sebestyén, Edina, Szavicskó, István, Vonderviszt, Ferenc, Végh, Barbara Márta, Závodszky, Péter   +18 more
core  

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Effects of freezer storage time on levels of complement biomarkers

BMC Research Notes, 2017
Background There is uncertainty regarding how stable complement analytes are during long-term storage at – 80 °C. As part of our work program we have measured 17 complement biomarkers (C1q, C1 inhibitor, C3, C3a, iC3b, C4, C5, C9, FB, FD, FH, FI, TCC, Bb,
Angharad R. Morgan, Caroline O’Hagan, Samuel Touchard, Simon Lovestone, B. Paul Morgan   +4 more
doaj   +1 more source