Results 151 to 160 of about 23,738 (171)

Complement Activation And C1q Binding Activity In Haemodialysis

Thrombosis and Haemostasis, 1981
It has been proposed that hypoxia occurring during Haemodialysis (HD) is related to complement activation by the dialysis membrane. Consequent leucocyte aggregation may then lead to pulmonary micro-embolisation. We set out to assess complement activation during HD using a new, sensitive, assay for activation fragment C3d.Twenty patients, established on
N J, Dodd, D, Vergani, J H, Turney, V, Parsons, M J, Weston   +4 more
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Detection of complement C1q receptors on human spermatozoa

Journal of Reproductive Immunology, 1998
Clq, the first component of the classical complement pathway, is known to play roles in promoting phagocytic events, in addition to its role in activation of complement. Although the molecular events in fertilization leading to the entrance of the spermatozoan into the egg are not well understood, ultrastructural observations suggest that the process ...
R, Bronson, S, Bronson, L, Oula, W, Zhang, B, Ghebrehiwet   +4 more
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Complement C1q Does Not Bind Monomeric β-Amyloid

Experimental Neurology, 1994
The tendency of both labeled and unlabeled beta-amyloid to bind in solution to C1q, the recognition species in the complement cascade, was examined using both hydrodynamic and spectroscopic methods. Potential binding interactions were evaluated using a purified synthetic beta-amyloid 1-40 sequence, alone, and selectively labeled at the amino terminus ...
S W, Snyder, G T, Wang, L, Barrett, U S, Ladror, D, Casuto, C M, Lee, G A, Krafft, R B, Holzman, T F, Holzman   +8 more
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Roles of Complement C1q in Pneumococcus-Host Interactions

Critical Reviews in Immunology, 2015
The fight between a human host and a bacterial pathogen is highly complicated; each party tries to outshine the other in the race for survival. In humans, the innate immune system--in particular the complement system--functions as the first line of defence against invading pathogens.
Vaibhav, Agarwal, Anna M, Blom
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Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction

Developmental & Comparative Immunology, 2020
Complement component 1q (C1q), together with C1r and C1s to form C1, recognize and bind immune complex to initiate the classical complement pathway. In this study, C1q subunit molecules (XlC1qA, XlC1qB, XlC1qC) were cloned and analyzed from Xenopus laevis (X. laevis).
Fangfang, Yan, Enxu, Zhou, Shuo, Liu, Along, Gao, Linghe, Kong, Bingxi, Li, Xiao, Tu, Zheng, Guo, Jinfeng, Mo, Meng, Chen, Jianmin, Ye   +10 more
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Adsorption of Complement Proteins C3 and C1q

Journal of Colloid and Interface Science, 1996
Abstract Surface localization plays a key but ill defined role in activation of the serum complement system with or without related “opsonic” proteins. The adsorption of key complement components C3 and C1q and various opsonins, e.g., IgG, were therefore studied on different surfaces usingin situellipsometry.
Martin Malmsten, Bo Lassen, James M. Van Alstine, Ulf R. Nilsson   +3 more
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C1q component of complement binds to fibrinogen and fibrin

Biochemistry, 1988
The interaction of complement component C1q with fibrinogen and fibrin was studied by using a solid-phase direct binding assay. Scatchard analysis of radioiodinated fibrinogen binding to C1q indicated at least two high-affinity binding constants (Kd) calculated as 8.5 and 120 nM. In contrast, binding of radioiodinated fibrin to C1q showed only a single
R A, Entwistle, L T, Furcht
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Differential chemokine response of fibroblast subtypes to complement C1q

Journal of Periodontal Research, 2006
Background and Objective:  The pathogenesis of periodontitis includes an inappropriate activation of the classical complement cascade (C′) with accumulation of inflammatory C′ products in fluids and tissues. Our hypothesis is that in vivo the C′ product, C1q, may act as a regulatory component of the innate immune response of distinct matrix fibroblasts
S, Verardi, R C, Page, W F, Ammons, S, Bordin   +3 more
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Binding of complement component C1q by rat adipocyte membranes

Molecular Immunology, 1985
Human C1q was found to bind to rat adipocyte membranes with an affinity comparable to that for aggregated immunoglobulin. The binding was ionic strength dependent, and modification of arginyl and histidyl residues in C1q abrogated its binding activity.
A, Comis, S B, Easterbrook-Smith
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Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis

Molecular Immunology, 2008
Autoantibodies against complement C1q (anti-C1q) strongly correlate with the occurrence of severe lupus nephritis. Recent data suggest that anti-C1q might also correlate with more severe forms of acute post-streptococcal glomerulonephritis (APSGN). Therefore, we prospectively investigated the role of anti-C1q in 50 children with newly diagnosed APSGN ...
Kozyro, I., Korosteleva, L., Chernoshej, D., Danner, D., Sukalo, A., Trendelenburg, M.   +5 more
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