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Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement
Agathe Bélime+11 more
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Complement Activation And C1q Binding Activity In Haemodialysis [PDF]
It has been proposed that hypoxia occurring during Haemodialysis (HD) is related to complement activation by the dialysis membrane. Consequent leucocyte aggregation may then lead to pulmonary micro-embolisation. We set out to assess complement activation during HD using a new, sensitive, assay for activation fragment C3d.Twenty patients, established on
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Binding of complement component C1q by spectrin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986125I-labelled human C1q was found to bind to human spectrin. Scatchard plots for the binding process were non-linear, indicating the possible presence of multiple classes of binding sites for C1q on spectrin. The binding was ionic-strength-dependent; the extent of binding decreased with increasing ionic strength.
Simon B. Easterbrook-Smith, Alfio Comis
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C1q: the perfect complement for a synaptic feast?
Nature Reviews Neuroscience, 2008The efficient and selective removal of apoptotic cells is an important feature of tissue development, homeostasis and pathology. In the nervous system, synapses and distal axons are selectively eliminated as part of the remodelling that underpins development and pathology, through a process that has some features in common with apoptotic cell removal ...
Perry, V. Hugh, O'connor, Vincent
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Clinical implications and mechanism of complement C1q in polymyositis
Applied Biochemistry and Biotechnology, 2023Polymyositis (PM) is the most common autoimmune disease in neurology and among muscle disorders; it is of great significance to thoroughly understand the mechanism of PM to find new diagnosis and treatment methods. This research intends to elucidate the clinical implications and mechanisms of complement C1q in polymyositis (PM).
Di Wu+6 more
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Complement and C1q Binding Substances in Otitis Media
Annals of Otology, Rhinology & Laryngology, 1980Complement activation, as shown by increased amounts of complexes composed of Clr-Cls-Cl IA, and abnormal complexes of Clr-Cls were demonstrated in serum from patients with acute pneumococcal and chronic otitis media, serous or mucoid respectively. C1q binding substances were shown in middle ear effusions and in sera from patients with chronic serous ...
A. B. Laurell+3 more
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