Results 261 to 270 of about 40,238 (270)
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Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia
Experimental Neurology, 2000Recent studies showing that microglia internalize the amyloid beta-peptide (Abeta) suggest that these cells have the potential for clearing Abeta deposits in Alzheimer's disease, and mechanisms that regulate the removal of Abeta may therefore be of clinical interest.
Larry Margol +5 more
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Binding of complement component C1q by rat adipocyte membranes
Molecular Immunology, 1985Human C1q was found to bind to rat adipocyte membranes with an affinity comparable to that for aggregated immunoglobulin. The binding was ionic strength dependent, and modification of arginyl and histidyl residues in C1q abrogated its binding activity.
Simon B. Easterbrook-Smith, A. Comis
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Differential chemokine response of fibroblast subtypes to complement C1q
Journal of Periodontal Research, 2006Background and Objective: The pathogenesis of periodontitis includes an inappropriate activation of the classical complement cascade (C′) with accumulation of inflammatory C′ products in fluids and tissues. Our hypothesis is that in vivo the C′ product, C1q, may act as a regulatory component of the innate immune response of distinct matrix fibroblasts
Roy C. Page +3 more
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Activation of Mammalian Complement by Chicken C1q
1983Activation of chicken complement by the classical pathway is still debatable. Both positive and negative evidence of antibody dependent lysis has been reported. The components from C3 to C9 function since activation via the alternative pathway will lyse mammalian erythrocytes in the absence of Ig.
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Complement C1q Does Not Bind Monomeric β-Amyloid
Experimental Neurology, 1994The tendency of both labeled and unlabeled beta-amyloid to bind in solution to C1q, the recognition species in the complement cascade, was examined using both hydrodynamic and spectroscopic methods. Potential binding interactions were evaluated using a purified synthetic beta-amyloid 1-40 sequence, alone, and selectively labeled at the amino terminus ...
D. Casuto +8 more
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Binding of C1q and complement activation by vascular endothelium.
The Journal of Immunology, 1981Abstract Exposure of intermediate filaments of cultured cells to serum leads to antibody-independent binding of complement (C) component C1q, C4, and C3. The apparent C-activating property of cytoskeletal intermediate filaments was examined on a tissue level in The present study by using frozen sections of human kidney and term placentas
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The C1q complement family of synaptic organizers: not just complementary
Current Opinion in Neurobiology, 2017Molecules that regulate formation, differentiation, and maintenance of synapses are called synaptic organizers. Recently, various 'C1q family' proteins have been shown to be released from neurons, and serve as a new class of synaptic organizers. Cbln1 and C1ql1 proteins regulate the formation and maintenance of parallel fiber-Purkinje cell and climbing
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Biochemical Specificity of Human Complement Component C1q [PDF]
, 1983 The serum complement system has an important role in host defense and haemostasis, and inflammatory processes1. It consists of 9 components, 2 factors and 9 regulatory processes2,3. With the exception of factor D, the complement proteases circulate in vivo as zymogens which are activated to a system of interacting transiently active proteases by ...
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Clq protein of human complement
Biochemistry, 1972Calcott Ma, Müller-Eberhard Hj
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Gross conformation of C1q: a subcomponent of the first component of complement
Biochemistry, 1978Stephen M. Paul, Paul A. Liberti
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