Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein [PDF]
Frontiers in Immunology, 2021 The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Aleksandra Urban +15 more
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Characterization of Schistosoma japonicum tetraspanning orphan receptor and its role in binding to complement C2 and immunoprotection against murine schistosomiasis [PDF]
Parasites & Vectors, 2017 Background Schistosomiasis remains an important global public health problem, as millions of people are at risk of acquiring infection. An ideal method for sustainable control of schistosomiasis would be to develop an efficient vaccine.
Shuai Ma +10 more
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In Silico Designed Gain-of-Function Variants of Complement C2 Support Cytocidal Activity of Anticancer Monoclonal Antibodies. [PDF]
Cancers (Basel), 2022 Simple Summary The complement system can be exploited by anticancer antibody-based therapeutics. Activation of the classical complement pathway by the heavy chain of antibodies eventually leads to the lysis of target cells.
Urban A +7 more
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Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein [PDF]
Frontiers in Immunology, 2022 The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation ...
Alicja Kuźniewska +12 more
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Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance? [PDF]
Journal of Innate Immunity, 2023 The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C ...
Marco Mannes +16 more
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Definitions, 2020 Complement C2 is a single chain serum glycoprotein (110 kDa), which serves as the catalytic subunit of C3 and C5 convertases in the classical and lectin pathways.
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Type II Human Complement C2 Deficiency [PDF]
Journal of Biological Chemistry, 1996 Type II complement protein C2 deficiency is characterized by a selective block in C2 secretion. The Type II C2 null allele (C2Q0) is linked to two major histocompatibility haplotypes (MHC) that differ from the MHC of the more common Type I C2 deficiency.
Rick A. Wetsel +7 more
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Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor [PDF]
The Journal of Immunology, 2005 AbstractThe complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and membrane regulators. We describe complement C2 receptor inhibitor trispanning (CRIT), a novel human complement regulatory receptor, expressed on hemopoietic cells and a wide range of ...
Jameel M, Inal +7 more
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Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C2 [PDF]
The Journal of Immunology, 2002 AbstractComplement C2 receptor inhibitor trispanning (CRIT) of the Schistosoma parasite binds human C2 via the C2a segment. The receptor in vivo functions as C2 decoy receptor by directly competing with C4b for binding to C2. As a result, CRIT is able to limit the extent of classical pathway (CP) C3 convertase formation.
Jameel M, Inal, Jürg A, Schifferli
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Quantification of human complement C2 protein using an automated turbidimetric immunoassay [PDF]
Clinical Chemistry and Laboratory Medicine (CCLM), 2018 AbstractBackground:The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease. C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis. In this study, we have evaluated The Binding
Tange, Clare Elizabeth +12 more
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