Differential complement pathways and components in the clinical spectrum of systemic lupus erythematosus [PDF]
Arthritis Research & TherapyObjectives The precise contributions of the classical (CP), lectin (LP), and alternative (AP) pathways to systemic lupus erythematosus (SLE) remain incompletely understood.
Haijun Ma +3 more
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Complement C2 receptor inhibitor trispanning: from man to schistosome [PDF]
Springer Seminars in Immunopathology, 2005 Horizontal gene transfer (HGT), in relation to genetic transfer between hosts and parasites, is a little described mechanism. Since the complement inhibitor CRIT was first discovered in the human Schistosoma parasite (the causative agent of Bilharzia) and in Trypanosoma cruzi (a parasite causing Chagas' disease), it has been found to be distributed ...
J. Inal
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Development of an anti-rat complement C2 antibody that improves renal outcome in a rat kidney transplant model [PDF]
Frontiers in ImmunologyBackgroundPreviously we reported on the therapeutic monoclonal anti-human C2 antibody empasiprubart that inhibits activation of the classical and lectin pathways of complement.
Laura Bracke +8 more
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Effect of olanzapine on changes in serum complement factors levels in patients with first-episode schizophrenia [PDF]
BMC PsychiatryObjective An increasing number of studies have demonstrated that patients with schizophrenia (SCZ) exhibit complement system disorders, and alterations in serum complement factor levels may serve as biomarkers for guiding the diagnosis, prognosis, and ...
Yin Cao +5 more
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Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart [PDF]
Nature CommunicationsActivation of classical and lectin complement pathways contributes to several human diseases. Empasiprubart is a humanized recycling monoclonal antibody that inhibits both pathways by binding to the CCP2 domain of complement factor 2 (C2), an interaction
Inge Van de Walle +13 more
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Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases. [PDF]
J Biol Chem, 2016 Mortensen S, Jensen JK, Andersen GR.
europepmc +2 more sources
Machine learning-based identification of extracellular matrix-related prognostic subtypes in SHH-activated medulloblastoma [PDF]
Discover OncologyBackground Medulloblastoma (MB) is the most common malignant pediatric brain tumor, with the Sonic Hedgehog (SHH) subgroup exhibiting heterogeneous clinical outcomes.
Qingshuang Zhao +7 more
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Alternatively spliced transcripts of the human complement C2 gene.
The Journal of Immunology, 1994 Abstract To investigate the possible presence of alternatively spliced C2 gene transcripts, we amplified mRNA from HepG2 cells by reverse transcription-PCR using primers derived from the 5' and 3' untranslated regions of the C2 mRNA. Cloning of the resulting products revealed the presence of four novel C2 mRNA size variants.
J, Cheng, J E, Volanakis
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Impact of complement system proteins on the clinical progression of hospitalized patients with COVID-19 [PDF]
BMC Infectious DiseasesBackground The complement system is an important defense mechanism against pathogens, including viruses. In COVID-19, evidence suggests that hyperactivation of the complement system can lead to tissue damage and provoke dysregulation of the coagulation ...
Lorena Viana de Andrade +5 more
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Biomedicines, 2022 The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino +11 more
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