Results 221 to 230 of about 994,718 (258)

Complement C2 siRNA mediated therapy of myasthenia gravis in mice

Journal of Autoimmunity, 2013
Activation of complement components is crucial in the progression and severity of myasthenia gravis and experimental autoimmune myasthenia gravis (EAMG). Mice deficient in complement component C4 or treated with monoclonal antibody to C1q are resistant to EAMG.
Ruksana, Huda, Erdem, Tüzün, Premkumar, Christadoss   +2 more
openaire   +3 more sources

Genetic polymorphism of the complement C2 in Japanese

Human Genetics, 1981
Genetic polymorphism of the second component of human complement (C2) was investigated in 521 unrelated healthy adult Japanese using isoelectric focusing in polyacrylamide gel followed by a specific hemolytic overlay method. Besides the phenotypes reported previously (C, AC and BC), a relatively infrequent double-banded phenotype (tentatively named A'C)
K, Tokunaga, C, Araki, T, Juji, K, Omoto
openaire   +3 more sources

Polymorphism of the Second Component of Human Complement (C2)

Vox Sanguinis, 1979
Abstract. The polymorphism of the second component of human complement was studied by means of isoelectric focusing in polyacrylamide gels with subsequent complement‐dependent lysis of sensitized sheep erythrocytes in an agarose overlay containing C2‐deficient or normal human serum.
G. Dewald, C. Rittner
semanticscholar   +3 more sources

Measurement of Complement C2 using the binding site SPAPLUS® turbidimetric analyzer and Complement C2 assay

Clinica Chimica Acta, 2019
H. Brook, B. Johnson-Brett, F. Brohet, P. Stordeur, D. Mcentee, F. Murphy, D. Matters, S. Harding   +7 more
openaire   +2 more sources

Deficiency of the Second Component of Complement (C2) with Chronic Vasculitis

Annals of Internal Medicine, 1975
A patient had complete deficiency of the second component of complement associated with chronic vasculitis and increased susceptibility to infection. We discuss here results of the complement profile, histocompatibility typing, and studies of the functional properties of patient plasma or serum in chemotaxis and opsonization in relation to the disease ...
PETER FRIEND, JOHN E. REPINE, YOUNGKI KIM, C. C. CLAWSON, ALFRED F. MICHAEL   +4 more
openaire   +3 more sources

HEREDITARY COMPLEMENT (C2) DEFICIENCY WITH DISCOID LUPUS ERYTHEMATOSUS AND IDIOPATHIC ATROPHODERMA

International Journal of Dermatology, 1979
ABSTRACT. A Family with hereditary deficiency of the second component of complement was studied. Three siblings were homozygous for C2 deficiency and two of them had associated skin diseases. Ono sister presented with idiopathic atrophoderma and the other had clinical and pathological manifestations of discoid lupus erythematosus.
M M, de Bracco, C A, Bianchi, O, Bianchi, S G, Stringa   +3 more
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Lymphokine and phorbol (PMA) regulation of complement (C2) synthesis using U937

Cellular Immunology, 1983
Human monocytes synthesize large amounts of the second complement component (C2) after incubation with a T-lymphocyte product called monocyte complement stimulator (MCS). The human monocyte-like cell line, U937, also synthesizes C2 and can be stimulated to increase this synthesis by lymphokine-rich culture supernates.
B H, Littman, R E, Hall, A V, Muchmore
openaire   +3 more sources

HLA-linked complement polymorphisms (C2, BF) in psoriasis

Archives of Dermatological Research, 1983
Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF.
G, Dewald, C E, Lange, E, Schmeel, H W, Kreysel   +3 more
openaire   +2 more sources

Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency

medRxiv
Background: Primary amoebic meningoencephalitis (PAM) is a rapidly progressive and often fatal central nervous system infection caused by Naegleria fowleri.
J. Cui, Colleen M Roark, N. Domínguez-Pinilla, P. Nozal Aranda, Begoña Losada, Pilar Zamarrón, Jacob Lorenzo-Morales, J. M. Rubio Muñoz, Megan M Dobrose, Ana Van Den Rym, Luis M. Allende, Catherine D. Shelton, Dante E. Reyna, Janet Markle, Santiago Rodríguez de Córdoba, Margarita Lôpez-Trascasa, R. Pérez de Diego, C. H. Serezani, Mariana X. Byndloss, Isabel de Fuentes Corripio, L. González‐Granado, Ruben Martinez-Barricarte   +21 more
semanticscholar   +1 more source

Human complement component C2: Production and characterization of polyclonal and monoclonal antibodies against C2

Molecular Immunology, 1986
Rabbit antibodies to human complement component C2 were produced by immunization of rabbits with precipitates from line immunoelectrophoresis, and the antibodies were used to monitor a classical chromatographic purification of C2 and for affinity purification of C2.
E I, Stenbaek, C, Koch, V, Barkholt, K G, Welinder   +3 more
openaire   +2 more sources