Results 231 to 240 of about 994,718 (258)

HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics.

Diabetes Research and Clinical Practice, 1985
A series of diabetic patients from 3 centres in South India have been tested for HLA A, HLA B, BF, C2, C4A, C4B and GLO types. For insulin-dependent diabetes mellitus (IDDM) patients there was a significant increase in HLA B8, of BF F and decrease of C4 ...
R. Kirk, P. Ranford, S. Serjeantson, A. Thompson, S. M. Munirathnam Chetty, L. John, V. Mohan, Ambady Ramachandran, C. Snehalatha, M. Viswanathan   +9 more
semanticscholar   +1 more source

Complement Component C2, Inhibiting a Latent Serine Protease in the Classical Pathway of Complement Activation

Biochemistry, 2009
The innate immune response to infection or injury involves an antigen-antibody triggered classical pathway (CP) of complement activation, in which soluble and cell surface plasma proteins cooperatively effect elimination of foreign organisms and damaged host cells.
Halili, Maria A., Ruiz-Gomez, Gloria, Le, Giang T., Abbenante, Giovanni, Fairlie, David P.   +4 more
openaire   +3 more sources

Characterization of type I complement C2 deficiency MHC haplotypes. Strong conservation of the complotype/HLA-B-region and absence of disease association due to linked class II genes.

Journal of Immunology, 1993
Fourteen individuals with complete C2 deficiency from 11 families and 3 heterozygous C2-deficient individuals from two families were investigated. In all the 24 independent C2-deficient haplotypes, the complotype S042 was present and the majority (21/24)
L. Truedsson, C. Alper, Z. Awdeh, P. Johansen, A. Sjöholm, G. Sturfelt   +5 more
semanticscholar   +1 more source

Structure and activation of complement components C2 and Factor B

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984
The activation of complement is initiated by two independent pathways. Each leads to the formation of a complex protease, C3 convertase, with equivalent specificity and function but different composition. The convertase derived from the classical pathway is composed of complement components C4 and C2 while that from the alternative pathway consists of ...
openaire   +2 more sources

cDNA cloning and expression of human complement component C2.

The Journal of Immunology, 1989
Abstract A full-length cDNA clone for C component C2 was isolated from a human liver cDNA library in lambda gt11 by initially screening with an affinity-purified rabbit anti-C2 antibody and then using the isolated partial C2 cDNA as a probe for re-screening the library.
T, Horiuchi, K J, Macon, V J, Kidd, J E, Volanakis   +3 more
openaire   +2 more sources

A new, simplified method for oxidation of human complement component C2

Journal of Immunological Methods, 1990
Oxy C2 is a valuable immunologic reagent, particularly for investigators whose research or clinical assays require a stable classical pathway C3 and/or C5 convertase or a highly active plasma complement source. To date only one method for the conversion of serum C2 or purified C2 to their respective oxy C2 forms has been published. However, this method
C M, Brickman, J P, Atherton, N L, Kantor   +2 more
openaire   +2 more sources

Monocyte complement stimulator: A T-lymphocyte product which stimulates synthesis of the second complement component (C2)

Cellular Immunology, 1979
Abstract Monocyte complement stimulator (MCS), a lymphokine previously shown to increase the rate of synthesis of the second complement component (C2) by human monocytes, is produced by sensitive T lymphocytes when exposed to antigen. MCS production requires cooperation of T lymphocytes with monocytes during the first 24 hr of exposure to antigen ...
B H, Littman, S, Ruddy
openaire   +2 more sources

Biosynthesis of a structurally abnormal C2 complement protein by macrophages from C2-deficient guinea pigs.

The Journal of Immunology, 1982
Abstract In order to characterize a genetic deficiency of C2 in guinea pigs, production of C2 by peritoneal macrophage cultures derived from four normal, four heterozygous deficient, and four homozygous deficient animals was measured functionally and immunochemically after metabolic labeling with 35S-methionine.
G, Goldberger, F S, Cole, L P, Einstein, H S, Auerbach, D, Bitter-Suermann, H R, Colten   +5 more
openaire   +2 more sources

The Second Complement Component, C2, in the Ninth Workshop

1984
Since the invention of the hemolytic overlay technique to reveal the presence of C2 in gels after isoelectric focusing [1, 4, 5], studies have been made in several populations [reviewed in 6], initially in Caucasoids and latterly in Mongoloids. In all groups studied, polymorphism of C2 has been shown.
W. H. Marshall, M. Neugebauer, M. P. Baur, E. D. Albert   +3 more
openaire   +1 more source

Complement C2 deficiency disarranging innate and adaptive humoral immune responses in a pediatric patient: Treatment with rituximab

Arthritis care & research, 2011
F. Hauck, M. Lee-Kirsch, D. Aust, J. Roesler, F. Pessler   +4 more
semanticscholar   +1 more source