Results 21 to 30 of about 994,718 (258)

ARGX-117, a therapeutic complement inhibiting antibody targeting C2 [PDF]

Journal of Allergy and Clinical Immunology, 2021
Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and ischemia-reperfusion conditions. Complement factors are being considered as targets for therapeutic intervention.We sought to characterize ARGX-117, a humanized inhibitory monoclonal antibody against ...
Inge Van de Walle, Karen Silence, Kevin Budding, Liesbeth Van de Ven, Kim Dijkxhoorn, Elisabeth de Zeeuw, Cafer Yildiz, Sofie Gabriels, Jean-Michel Percier, Johanna Wildemann, Jan Meeldijk, Peter J. Simons, Louis Boon, Linda Cox, Rob Holgate, Rolf Urbanus, Henny G. Otten, Jeanette H.W. Leusen, Christophe Blanchetot, Hans de Haard, C. Erik Hack, Peter Boross   +21 more
openaire   +3 more sources

Hypoglycemia-induced changes in complement pathways in type 2 diabetes

Atherosclerosis Plus, 2021
Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothesized
Abu Saleh Md Moin, Manjula Nandakumar, Ilhame Diboun, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler   +6 more
doaj   +1 more source

Gain-of-function mutation in complement C2 protein identified in patient with aHUS.

Journal of Allergy and Clinical Immunology, 2020
CAPSULE SUMMARY Complement convertases resistant to their physiological inhibitors may cause complement-related glomerulopathies. S250C substitution in complement C2 found in aHUS patient results in formation of overactive classical complement convertase
A. Urban, E. Volokhina, Anna Felberg, Grzegorz Stasiłojć, A. Blom, I. Jongerius, L. P. Van den Heuvel, M. Thiel, S. Ołdziej, Emilia Arjona, S. R. de Córdoba, M. Okrój   +11 more
semanticscholar   +1 more source

C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. [PDF]

PLoS ONE, 2008
Age-related maculopathy (ARM) is a common cause of visual impairment in the elderly populations of industrialized countries and significantly affects the quality of life of those suffering from the disease.
Johanna Jakobsdottir, Yvette P Conley, Daniel E Weeks, Robert E Ferrell, Michael B Gorin   +4 more
doaj   +1 more source

A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway

Virulence, 2023
Streptococcus equi subsp. zooepidemicus (SEZ) is a major equine pathogen that causes pneumonia, abortion, and polyarthritis. It can also cause invasive infections in humans.
René Bergmann, Wieland Schroedl, Uwe Müller, Christoph Georg Baums   +3 more
doaj   +1 more source

C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice

Frontiers in Immunology, 2020
Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2 binds to a subset of phospholipids displayed on injured cells, and its role(s) in arthritis, as ...
Nirmal K. Banda, Stephen Tomlinson, Robert I. Scheinman, Nhu Ho, Nhu Ho, Joseline Ramos Ramirez, Gaurav Mehta, Guankui Wang, Vivian Pham Vu, Dmitri Simberg, Liudmila Kulik, V. Michael Holers   +11 more
doaj   +1 more source

Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s

Frontiers in Immunology, 2023
ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye, Jun Ye, Jie Xu, Chuanmeng Zhang, Li Zhu, Sheng Xia   +5 more
doaj   +1 more source

Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases

BMC Immunology, 2010
Background Complement C2 deficiency is the most common genetically determined complete complement deficiency and is associated with a number of diseases.
Martini Paolo GV, Cook Lynette C, Alderucci Scott, Norton Angela W, Lundberg Dianna M, Fish Susan M, Langsetmo Knut, Jönsson Göran, Lood Christian, Gullstrand Birgitta, Zaleski Kate J, Savioli Nancy, Lottherand Jason, Bedard Charles, Gill John, Concino Michael F, Heartlein Michael W, Truedsson Lennart, Powell Jan L, Tzianabos Arthur O   +19 more
doaj   +1 more source

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
doaj   +1 more source

Proteomic profiling of IgA nephropathy reveals distinct molecular prognostic subtypes

iScience, 2023
Summary: IgA nephropathy (IgAN) is a heterogeneous disease, which poses a series of challenges to accurate diagnosis and personalized therapy. Herein, we constructed a systematic quantitative proteome atlas from 59 IgAN and 19 normal control donors ...
Xizhao Chen, Mansheng Li, Songbiao Zhu, Yang Lu, Shuwei Duan, Xu Wang, Yong Wang, Pu Chen, Jie Wu, Di Wu, Zhe Feng, Guangyan Cai, Yunping Zhu, Haiteng Deng, Xiangmei Chen   +14 more
doaj   +1 more source