Results 31 to 40 of about 994,718 (258)

Nomenclature for human complement component C2 [PDF]

Journal of Immunological Methods, 1993
Abstract This note describes the recommended designations for allotypes of human complement component C4, which were approved by the Nomenclature Committee of the International Union of Immunological Societies (IUIS).
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Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy

Frontiers in Cellular Neuroscience, 2023
PurposeTo investigate the relationship between the intraocular levels of complement proteins and myopia-related retinal neuronal and vascular degeneration.MethodsAqueous humour from 147 myopic patients, including 60 low-myopia and 87 high-myopia were ...
Ling Zeng, Ling Zeng, Ling Zeng, Xiaoning Li, Xiaoning Li, Wei Pan, Yao Tang, Yao Tang, Ding Lin, Min Wang, Wang Cai, Ruiling Zhu, Jianbo Wan, Linghua Huang, Heping Xu, Heping Xu, Heping Xu, Zhikuan Yang, Zhikuan Yang, Zhikuan Yang   +19 more
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Complement-human histocompatibility antigen haplotypes in C2 deficiency. [PDF]

Journal of Clinical Investigation, 1981
C4 allotyping 13 homozygous C2-deficient individuals demonstrated 23 of 25 haplotypes to be of the relatively rare type C4A4 B2. This is of the same magnitude as the association of C2Q0 with HLA-DW2/DR2.
Z L, Awdeh, D D, Raum, D, Glass, V, Agnello, P H, Schur, R B, Johnston, E W, Gelfand, M, Ballow, E, Yunis, C A, Alper   +9 more
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Hereditary Deficiency of the Second Component of Complement: Early Diagnosis and 21-Year Follow-Up of a Family

Medicina, 2020
Complement deficiencies are rare and often underdiagnosed primary immunodeficiencies that may be associated with invasive bacterial diseases. Serious infections with encapsulated organisms (mainly Streptococcus pneumoniae, but also Neisseria meningitides
Rosa Maria Dellepiane, Lucia Augusta Baselli, Marco Cazzaniga, Vassilios Lougaris, Paolo Macor, Mara Giordano, Roberta Gualtierotti, Massimo Cugno   +7 more
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C2 by-pass: Cross-talk between the complement classical and alternative pathways

Immunobiology, 2022
Several disorders associated with the total or partial absence of components of the human complement system are known. Deficiencies of classical pathway (CP) components are generally linked to systemic lupus erythematosus (SLE) or SLE-like syndromes. However, only approximately one-third of patients who lack C2 show mild symptoms of SLE. The relatively
Laich, A., Patel, H., Zarantonello, A., Sim, R. B., Inal, J. M.   +4 more
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Identification of Complin, a Novel Complement Inhibitor that Targets Complement Proteins Factor B and C2 [PDF]

The Journal of Immunology, 2010
Abstract Complement factor B (fB) is a key constituent of the alternative pathway (AP). Its central role in causing inflammation and tissue injury through activation of the AP urges the need for its therapeutic targeting. In the current study, we have screened phage-displayed random peptide libraries against fB and identified a novel ...
Archana P, Kadam, Arvind, Sahu
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Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. [PDF]

PLoS ONE, 2014
We have previously reported that in vitro HCV infection of cells of hepatocyte origin attenuates complement system at multiple steps, and attenuation also occurs in chronically HCV infected liver, irrespective of the disease stage. However, none of these
Hangeun Kim, Keith Meyer, Adrian M Di Bisceglie, Ranjit Ray   +3 more
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Systemic complement activation in age-related macular degeneration. [PDF]

PLoS ONE, 2008
Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of
Hendrik P N Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G Fritsche, Ngaihang V Chong, Rolf Fimmers, Thomas Wienker, Frank G Holz, Bernhard H F Weber, Martin Oppermann   +12 more
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Complement factor B/C2 in molluscs regulates agglutination and illuminates evolution of the Bf/C2 family [PDF]

The FASEB Journal, 2019
Complement factor B/C2 family (Bf/C2F) proteins are core complement system components in vertebrates that are absent in invertebrates and have been lost by numerous species, raising evolutionary questions. At least 3 duplication events have occurred from Cnidaria (ancestor) to mammals. Type II Bf/C2 genes appeared during separation
Maoxiao, Peng, Zhi, Li, Donghong, Niu, Xiaojun, Liu, Zhiguo, Dong, Jiale, Li   +5 more
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Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study

Journal of Neuroinflammation, 2022
Background Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers
Emma L. van der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Yolande A. L. Pijnenburg, Markus Otto, Barbara Borroni, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Daniela Galimberti, Sandro Sorbi, Henrik Zetterberg, Eric Huang, John C. van Swieten, Jonathan D. Rohrer, Harro Seelaar, the Genetic Frontotemporal Dementia Initiative (GENFI)   +44 more
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