Results 51 to 60 of about 994,718 (258)

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +1 more source

Plasma complement component C2: a potential biomarker for predicting abdominal aortic aneurysm related complications

Scientific Reports, 2022
Blood-based adjunctive measures that can reliably predict abdominal aortic aneurysm (AAA)-related complications hold promise for mitigating the AAA disease burden.
Tiam Feridooni, Abdelrahman Zamzam, Mariya Popkov, Muzammil H. Syed, Niousha Djahanpour, Mark Wheatcroft, Rawand Abdin, Mohammad Qadura   +7 more
doaj   +1 more source

Complement C2 polymorphisms in children with Henoch Schönlein purpura

Cukurova Medical Journal, 2020
Purpose: The aim of this study was to investigate whether C2 polymorphisms influence the symptoms and disease outcomes in children with Henoch Schönlein purpura (HSP).Materials and Methods: This cross-sectional study included 49 children with HSP, diagnosed and followed for at least 6 months in our department between July 2016 and March 2018.
Rabia Miray KİSLA EKİNCİ, Sibel BALCİ, Bahriye ATMİS, Aysun KARABAY BAYAZİT, Dilek DOGRUEL, Derya Ufuk ALTİNTAS, Atil BİSGİN   +6 more
openaire   +3 more sources

Studies of an additional kindred with hereditary deficiency of the second component of human complement (C2) and description of a new method for the quantitation of C2.

Journal of Immunology, 1968
The present paper reports studies of a third kindred which manifests the hereditary C2 deficiency trait. The homozygous individual had no detectable hemolytic serum complement or C2 activity, although C2 could be detected by immune adherence; three ...
N. Cooper, R. T. ten Bensel, P. Kohler
semanticscholar   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice

Cells
Chronic stress, a risk factor for many neuropsychiatric conditions, causes dysregulation in the immune system in both humans and animal models. Additionally, inflammation and synapse loss have been associated with deficits in social behavior.
Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pillai   +4 more
doaj   +1 more source

Peripheral Complement Factor-Based Biomarkers for Patients with First-Episode Schizophrenia

Neuropsychiatric Disease and Treatment, 2023
Yin Cao,1– 4 Yayun Xu,5– 7 Qingrong Xia,1– 4 Feng Shan,1– 4 Jun Liang1– 4 1Affiliated Psychological Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Pharmacy, Hefei Fourth People’s Hospital, Hefei, People’s Republic
Cao Y, Xu Y, Xia Q, Shan F, Liang J
doaj  

Modulating Two‐Photon Absorption in a Pyrene‐Based MOF Series: An In‐Depth Investigation of Structure–Property Relationships

Advanced Functional Materials, EarlyView.
This study investigates H4TBAPy‐based metal–organic frameworks (MOFs) ‐ NU‐1000, NU‐901, SrTBAPy, and BaTBAPy ‐ for multiphoton absorption (MPA) performance. It observes topology‐dependent variations in the 2PA cross‐section, with BaTBAPy exhibiting the highest activity.
Simon N. Deger, Helmy Pacheco Hernandez, Yang Cui, Hongxing Hao, Vanessa Ramm, David C. Mayer, Khai‐Nghi Truong, Roland A. Fischer, Jürgen Hauer, Mariana Kozlowska, Alexander Pöthig   +10 more
wiley   +1 more source

Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands. [PDF]

PLoS ONE, 2016
The human complement system is composed of more than 30 proteins and many of these have conserved domains that allow tracing the phylogenetic evolution.
Daniela Tiemi Myamoto, Giselle Pidde-Queiroz, Rute Maria Gonçalves-de-Andrade, Aurélio Pedroso, Carmen W van den Berg, Denise V Tambourgi   +5 more
doaj   +1 more source

Isolation of cDNA clones for human complement component C2. [PDF]

Proceedings of the National Academy of Sciences, 1984
Two cDNA clones for complement component C2 have been isolated from a high-complexity human liver cDNA library by using a mixture of 64 synthetic oligonucleotides as a probe. The 400-base-pair insert of pC201 codes for a region containing the active site serine residue and the secondary substrate binding pocket of the serine protease.
D R, Bentley, R R, Porter
openaire   +2 more sources