Results 111 to 120 of about 268,987 (334)

Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core  

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Francisella tularensis Confronts the Complement System

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
doaj   +1 more source

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Microbiome
Background Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression,
Wenzhi Hao, Qingyu Ma, Lu Wang, Naijun Yuan, Hua Gan, Liangliang He, Xiaojuan Li, Junqing Huang, Jiaxu Chen   +8 more
doaj   +1 more source

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

PLoS Pathogens, 2017
The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bacteria
Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan   +6 more
doaj   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K., Fraser, Robert J., Gunn, Bronwyn M., Heise, Mark T., Herrero, Lara J., Hueston, Linda, Mahalingam, Suresh, Morrison, Thomas E., Ramirez, Ruben, Smith, Paul N., Whitmore, Alan C.   +10 more
core   +1 more source

MONOCYTES FROM PATIENTS WITH GENETIC DEFICIENCY OF THE THIRD COMPONENT OF COMPLEMENT (C3) PRODUCE C3 IN VITRO [PDF]

, 1977
L P Einstein, Prudence J. Hansen, Chester A. Alper, John S. Davis, Fred S. Rosen, Mark Ballow, Harvey R. Colten   +6 more
openalex   +1 more source