Results 141 to 150 of about 862,879 (325)
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
eLifeAfrican trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathogens ...
Alexander D Cook +2 more
doaj +1 more source
The separation of functionally distinct forms of the third component of human complement (C3) [PDF]
, 1981 C.O. Parkes +3 more
openalex +1 more source
Advanced Science, EarlyView.Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge +7 more
wiley +1 more source
Defective binding of the third component of complement (C3) to Streptococcus pneumoniae in multiple myeloma [PDF]
, 1984 Cheson Bd +4 more
openalex +1 more source
, 2019 The complement system is one of the most ancient immune modulator mechanism of bilaterian metazoans, able to influence ancient cells and factors of both innate and adaptive immunity. Three complement-activation pathways are known in vertebrates: the classical, the alternative and the lectin pathways: all of them converge on the cleavage of C3.
Peronato A. +3 more
openaire +2 more sources
Advanced Science, EarlyView.Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh +11 more
wiley +1 more source
Binding of fluid-phase complement components C3 and C3b to human lymphocytes [PDF]
, 1981 Edith Sim, Robert B. Sim
openalex +1 more source
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
Science Translational Medicine, 2017 Qiaoqiao Shi +7 more
semanticscholar +1 more source
BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43
Advanced Science, EarlyView.This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan +13 more
wiley +1 more source
Molecular Chain Elongation Mechanism for n‐Caproate Biosynthesis by Megasphaera Hexanoica
Advanced Science, EarlyView.The medium‐chain carboxylate‐producing microbe Megasphaera hexanoica is analyzed through genomics, transcriptomics, and metabolic engineering. The n‐caproate biosynthetic pathway is reconstructed in Escherichia coli, highlighting MhTHL as a key β‐ketothiolase. Structural analysis and mutagenesis reveal that MhTHL has a distinct substrate‐binding pocket,
Byoung Seung Jeon +8 more
wiley +1 more source