Results 221 to 230 of about 82,726 (255)
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Complement C3 receptors: Structure and function
Molecular Immunology, 1984Significant progress has been made during the past few years toward elucidating the structure and function of various C3 receptors. Better understanding of the biochemical basis of the immune adherence phenomenon has been achieved. The availability of polyclonal and monoclonal antibodies to C3 receptors allowed more accurate studies of the cellular ...
M A, Arnaout, H R, Colten
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C3 and C6 Complement Types in Schizophrenia
Human Heredity, 1985C3 and C6 complement types were studied in schizophrenic patients and controls. The distributions of the three common C3 types (F, FS and S) among the patients was significantly different from that in the controls (p less than 0.005) and the frequency of the C3F gene was significantly increased (p less than 0.0005) among the patients.
C, Rudduck +3 more
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Treatment of C3 Glomerulopathy with Complement Blockers
Seminars in Thrombosis and Hemostasis, 2014C3 glomerulopathy (C3G) is a newly defined clinical entity comprising glomerular lesions with predominant C3 staining. Under this definition are now included membranoproliferative glomerulonephritis type II (dense deposit disease) and C3 glomerulonephritis.
Marina, Vivarelli, Francesco, Emma
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Complement C3 isoforms in Austrelaps superbus
Toxicon, 2008Complement C3 plays a pivotal role in both classical and alternate pathways. Lower organisms (urochordates and fishes) have multiple isoforms whereas higher organisms have a single C3 gene. In cobras, a closely related protein cobra venom factor (CVF) is expressed in their venom gland.
Syed, Rehana, R Manjunatha, Kini
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Interaction of Fibronectin with Complement Component C3
Scandinavian Journal of Immunology, 1983The activation of the complement component C3 generates C3a and C3b fragments, and the physiological cleavage of C3b further yields C3c and C3d fragments. We studied here by enzyme immunoassay the ability of human plasma fibronectin to interact with native C3 of human sera and with isolated C3c and C3d fragments of C3.
A, Hautanen, J, Keski-Oja
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Engineering of human complement component C3 for catalytic inhibition of complement
Immunology Letters, 2005As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Johanna, Kölln +2 more
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Complement, 2017
Some of the molecular events in the complement (C)-mediated solubilization of immune complexes (IC) have been clarified in recent years. The solubilization is primarily mediated by alternative C pathway proteins whereas factors in the classical pathway accelerate the process. Components of the membrane attack complex do not participate in the reaction.
Petersen, Ivan +3 more
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Some of the molecular events in the complement (C)-mediated solubilization of immune complexes (IC) have been clarified in recent years. The solubilization is primarily mediated by alternative C pathway proteins whereas factors in the classical pathway accelerate the process. Components of the membrane attack complex do not participate in the reaction.
Petersen, Ivan +3 more
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Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans
The Journal of Immunology, 1996Abstract The majority of complement protein C3 is synthesized by the liver, but many other cell types produce small amounts of functionally active C3. The overall contribution of such extrahepatic C3 production to the total circulating C3 level is unknown.
M A, Naughton +5 more
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Complement C3 and immunoglobulin in inflammatory acne vulgaris
British Journal of Dermatology, 1979In patients with moderate to severe inflammatory acne, complement (C3) was detected by immunofluorescence in sixteen early inflammatory acne lesions but in only one of thirteen biopsies of non-inflamed skin from acne sites. C3 deposition occurred particularly in the walls of small dermal blood vessels and at the dermo-epidermal junction.
M G, Dahl, D H, McGibbon
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