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Complement inhibition in C3 glomerulopathy
Seminars in Immunology, 2016C3 glomerulopathy (C3G) describes a spectrum of glomerular diseases defined by shared renal biopsy pathology: a predominance of C3 deposition on immunofluorescence with electron microscopy permitting disease sub-classification. Complement dysregulation underlies the observed pathology, a causal relationship that is supported by well described studies ...
Carla M, Nester, Richard J H, Smith
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Complement C3 proteins in psoriasis
British Journal of Dermatology, 1989A new polymorphism of the complement factor C3 in human plasma was demonstrated by isotachophoresis in agarose gels followed by immunodetection with rabbit anti-human C3c and C3d immunoglobulins. Four bands were detected in the immunoprint of freshly drawn EDTA-plasma, which were C3s1, C3s2, C3f1 and C3f2. At least four additional C3 components in Mg2+
F, Acevedo, H, Hammar
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Complement C3 in Bernese Mountain dogs
Veterinary Clinical Pathology, 2010Background:Previous research suggests that low serum concentrations of the third component of complement (C3) are associated with both the susceptibility to infectious agents such asBorrelia burgdorferiand the development of glomerular disease. We hypothesized that low levels of C3 are associated with the coincident occurrence ofB. burgdorferiinfection
Gerber, Bernhard +4 more
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Inherited complement C3 deficiency: A defect in C3 secretion
European Journal of Immunology, 1994AbstractThe molecular basis of inherited complement C3 deficiency in a 20‐year‐old newly diagnosed male patient was studied. Using an enzyme‐linked immunosorbent assay, the patient's C3 serum level was found to be approximately 7 μg/ml, which is less than 1 % of normal.
Y, Katz +4 more
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Complement C3 receptors: Structure and function
Molecular Immunology, 1984Significant progress has been made during the past few years toward elucidating the structure and function of various C3 receptors. Better understanding of the biochemical basis of the immune adherence phenomenon has been achieved. The availability of polyclonal and monoclonal antibodies to C3 receptors allowed more accurate studies of the cellular ...
M A, Arnaout, H R, Colten
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Complement C3 isoforms in Austrelaps superbus
Toxicon, 2008Complement C3 plays a pivotal role in both classical and alternate pathways. Lower organisms (urochordates and fishes) have multiple isoforms whereas higher organisms have a single C3 gene. In cobras, a closely related protein cobra venom factor (CVF) is expressed in their venom gland.
Syed, Rehana, R Manjunatha, Kini
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Treatment of C3 Glomerulopathy with Complement Blockers
Seminars in Thrombosis and Hemostasis, 2014C3 glomerulopathy (C3G) is a newly defined clinical entity comprising glomerular lesions with predominant C3 staining. Under this definition are now included membranoproliferative glomerulonephritis type II (dense deposit disease) and C3 glomerulonephritis.
Marina, Vivarelli, Francesco, Emma
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C3 glomerulopathy: A new complement-based entity
Revista Clínica Española (English Edition), 2014C3 glomerulopathy is a new, recently described entity that has changed the perspective, treatment and classification of a number of glomerular diseases. It encompasses 2 similar but clearly differentiated pathologies -the dense-deposit disease and C3 glomerulonephritis itself.
A, de Lorenzo +3 more
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Complement C3 recognition by C3 convertases
Abstract The complement system plays a fundamental role in human immunity, and its dysregulation is implicated in numerous diseases. Activation of the complement occurs through three main pathways: classical, lectin, and alternative; which converge at the central component, C3.Changhao Jia +4 more
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C3 and C6 Complement Types in Schizophrenia
Human Heredity, 1985C3 and C6 complement types were studied in schizophrenic patients and controls. The distributions of the three common C3 types (F, FS and S) among the patients was significantly different from that in the controls (p less than 0.005) and the frequency of the C3F gene was significantly increased (p less than 0.0005) among the patients.
C, Rudduck +3 more
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