Results 321 to 330 of about 268,987 (334)

Interaction of Fibronectin with Complement Component C3

Scandinavian Journal of Immunology, 1983
The activation of the complement component C3 generates C3a and C3b fragments, and the physiological cleavage of C3b further yields C3c and C3d fragments. We studied here by enzyme immunoassay the ability of human plasma fibronectin to interact with native C3 of human sera and with isolated C3c and C3d fragments of C3.
A, Hautanen, J, Keski-Oja
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Complement (C3)-Activated Phagocytosis by Lung Macrophages

The Journal of Immunology, 1978
Abstract We have investigated the interaction between rabbit lung macrophages and Escherichia coli lipopolysaccharide-coated oil droplets opsonized with a fragment of C3, and of albumin-coated oil droplets opsonized with anti-albumin IgG.
S B, Shurin, T P, Stossel
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The role of complement in C3 glomerulopathy

Molecular Immunology, 2015
C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated with C3 cleavage product deposition and with defective complement action and regulation (Fakhouri et al., 2010; Sethi et al., 2012b). Kidney biopsies from these patients show glomerular accumulation or deposition of C3 cleavage fragments, but no or minor deposition
Peter F. Zipfel, Christine Skerka, Qian Chen, Thorsten Wiech, Tim Goodship, Sally Johnson, Veronique Fremeaux-Bacchi, Clara Nester, Santiago Rodríguez de Córdoba, Marina Noris, Matthew Pickering, Richard Smith   +11 more
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Platelet-associated complement C3 in thrombocytopenic states

British Journal of Haematology, 1983
Platelet-associated complement components C3, C3d and C4 (PAC3, PAC3d, PAC4) were quantitated by a modification of the platelet radioactive anti-IgG test using highly purified C3 antibodies in 74 patients with immune thrombocytopenia (ITP), 26 patients with presumed nonimmune thrombocytopenia (NTP), and 114 normal individuals. Elevated PAC3 levels were
W, Kayser, C, Mueller-Eckhardt, S, Bhakdi, K, Ebert   +3 more
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Complement components (C3, C4) in childhood asthma

The Indian Journal of Pediatrics, 2005
To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma. Serum levels of complement components (C3, C4) were measured by radial immunodiffusion technique in 64 Libyan children (age:
F I E, Najam, A S M, Giasuddin, A H, Shembesh   +2 more
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Intracerebral hemorrhage in complement C3-deficient mice

2006
The complement cascade is activated and contributes to brain damage after intracerebral hemorrhage (ICH). The present study investigated ICH-induced brain damage in complement C3-deficient mice. This study was divided into 2 parts. Male C3-deficient and C3-sufficient mice received an infusion of 30-microl autologous whole blood into the right basal ...
S, Yang, T, Nakamura, Y, Hua, R F, Keep, J G, Younger, J T, Hoff, G, Xi   +6 more
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Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans

The Journal of Immunology, 1996
Abstract The majority of complement protein C3 is synthesized by the liver, but many other cell types produce small amounts of functionally active C3. The overall contribution of such extrahepatic C3 production to the total circulating C3 level is unknown.
M A, Naughton, M, Botto, M J, Carter, G J, Alexander, J M, Goldman, M J, Walport   +5 more
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Engineering of human complement component C3 for catalytic inhibition of complement

Immunology Letters, 2005
As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Johanna, Kölln, Reinhard, Bredehorst, Edzard, Spillner   +2 more
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Compound heterozygous complement C3 deficiency.

Immunology, 1995
Complete deficiency of the third component of the complement system is a result of defects in the two alleles of the C3 gene. In this study a family with C3 deficiency is reported; the parents expressed a distinct abnormality of the C3 gene and their two children had compound heterozygous C3 deficiency.
Y, Katz, R A, Wetsel, M, Schlesinger, Z, Fishelson   +3 more
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Recent developments in C3-targeted complement therapeutics

Seminars in Immunology, 2022
Dimitrios C, Mastellos, John D, Lambris
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