Results 81 to 90 of about 976,787 (206)

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Frontiers in Immunology, 2017
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood.
A. Lokki, T. Kaartokallio, V. Holmberg, P. Onkamo, L. Koskinen, P. Saavalainen, S. Heinonen, E. Kajantie, E. Kajantie, E. Kajantie, J. Kere, J. Kere, K. Kivinen, A. Pouta, A. Pouta, P. Villa, L. Hiltunen, H. Laivuori, S. Meri   +18 more
semanticscholar   +1 more source

Low Serum Complement C3 Levels at Diagnosis of Renal ANCA-Associated Vasculitis Is Associated with Poor Prognosis

PLoS ONE, 2016
Background Recent studies have demonstrated the key role of the complement alternative pathway (cAP) in the pathophysiology of experimental ANCA-associated vasculitis (AAV). However, in human AAV the role of cAP has not been extensively explored.
J. Augusto, V. Langs, J. Demiselle, C. Lavigne, Benoît Brilland, Agnès Duveau, C. Poli, A. Chevailler, A. Croué, F. Tollis, J. Sayegh, J. Subra   +11 more
semanticscholar   +1 more source

Serum complement C3 levels are associated with nonalcoholic fatty liver disease independently of metabolic features in Chinese population

Scientific Reports, 2016
Serum complement C3 levels are closely associated with obesity and related metabolic disorders. This study aimed to investigate the association between serum complement C3 levels with non-alcoholic fatty liver disease (NAFLD). A cross-sectional study was
Chengfu Xu, Yi Chen, Lei Xu, M. Miao, Youming Li, Chaohui Yu   +5 more
semanticscholar   +1 more source

Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the correlation between complement level of C3， other risk factors and cognitive dysfunction in patients with end-stage renal disease （ESRD）.MethodsFrom July 2019 to July 2021， medical records and laboratory examinations were ...
Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui   +5 more
doaj  

Cutaneous Vasculitis and Digital Ischaemia Caused by Heterozygous Gain-of-Function Mutation in C3

Frontiers in Immunology, 2018
It is now increasingly recognized that some monogenic autoinflammatory diseases and immunodeficiencies cause vasculitis, although genetic causes of vasculitis are extremely rare.
Ebun Omoyinmi, Ebun Omoyinmi, Iman Mohamoud, Kimberly Gilmour, Paul A. Brogan, Paul A. Brogan, Despina Eleftheriou, Despina Eleftheriou, Despina Eleftheriou   +8 more
doaj   +1 more source

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

Molecular & Cellular Proteomics, 2016
The slow but spontaneous and ubiquitous formation of C3(H2O), the hydrolytic and conformationally rearranged product of C3, initiates antibody-independent activation of the complement system that is a key first line of antimicrobial defense.
Zhuo A. Chen, R. Pellarin, L. Fischer, A. Sali, M. Nilges, P. Barlow, J. Rappsilber   +6 more
semanticscholar   +1 more source

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Frontiers in Immunology, 2018
Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases.
Seline A. Zwarthoff, Evelien T. M. Berends, Sanne Mol, Maartje Ruyken, Piet C. Aerts, Mihály Józsi, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Ronald D. Gorham   +8 more
doaj   +1 more source

Francisella tularensis Confronts the Complement System

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
doaj   +1 more source

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Journal of Neuroscience, 2015
The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via microglia-mediated pruning of inappropriate synapses during brain ...
Qiaoqiao Shi, Kenneth J. Colodner, S. Matousek, Katherine M. Merry, Soyon Hong, Jessica E. Kenison, J. Frost, Kevin X. Le, Shaomin Li, J. Dodart, B. Caldarone, B. Stevens, C. Lemere   +12 more
semanticscholar   +1 more source

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN

Frontiers in Immunology, 2018
Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a ...
Roberta Donadelli, Patrizia Pulieri, Rossella Piras, Paraskevas Iatropoulos, Elisabetta Valoti, Ariela Benigni, Giuseppe Remuzzi, Giuseppe Remuzzi, Giuseppe Remuzzi, Marina Noris   +9 more
doaj   +1 more source