Efficient chemical synthesis of human complement protein C3a [PDF]
Chemical Communications, 2013 We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was
Ames +27 more
core +5 more sources
Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity [PDF]
Journal of Translational Medicine, 2019 Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker +4 more
doaj +2 more sources
Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma. [PDF]
Cancer Biol Med, 2021 Jiang F +12 more
europepmc +3 more sources
Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice. [PDF]
Front Immunol, 2021 Pozo-Rodrigálvarez A +4 more
europepmc +3 more sources
Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy? [PDF]
BiologyEmerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins +5 more
doaj +2 more sources
Cytolytic effects of the complement cleavage product, C3a [PDF]
British Journal of Cancer, 1976 Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b.
J. Ferluga +3 more
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Changes in complement C3a in the immunotherapy of advanced clear cell renal cell carcinoma. [PDF]
Transl Androl UrolZhang C +6 more
europepmc +2 more sources
Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage. [PDF]
Front Neurosci, 2022 Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration. However, the mechanism of complement signaling in retinal degeneration needs to be further studied.
Wang S, Du L, Yuan S, Peng GH.
europepmc +4 more sources
Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia [PDF]
Brain, 2016 Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability.
Anna Stokowska +10 more
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Characterization of Synthetic C3a Analog Peptides on Human Eosinophils in Comparison to the Native Complement Component C3a [PDF]
The Journal of Immunology, 2000 Abstract The C3a anaphylatoxin is a potent proinflammatory mediator derived from the complement system inducing biologic effects of human eosinophils like Ca2+ transients and the activation of the respiratory burst. These findings support an important role for C3a in diseases typically associated with a peripheral blood or tissue ...
Holger Petering +7 more
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