Results 31 to 40 of about 26,149 (232)

Role of Complement Activation in Obliterative Bronchiolitis Post Lung Transplantation [PDF]

, 2013
Obliterative bronchiolitis (OB) post lung transplantation involves IL-17 regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation.
Benson, Heather L., Brown, Krista M., Devore, Denise, Fan, Lin, Gu, Hongmei, Lasaro, Melissa, Lasbury, Mark E., Lipking, Kelsey, Love, Robert, Mickler, Elizabeth A., Pandya, Pankita, Reynolds, John, Sandusky, George E., Shilling, Rebecca, Suzuki, Hidemi, Vittal, Ragini, Wagner, Sarah R., Wang, Yi, Weber, Daniel J., Wilkes, David S., Wozniak, Thomas, Wu, Qiang   +21 more
core   +2 more sources

Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]

, 1993
Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kroworsch, Peter, Schweiberer, Leonhard, Shimamoto, Kazuaki, Siebeck, Matthias, Spannagl, Michael, Weipert, Joachim   +8 more
core   +1 more source

The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]

PLoS ONE, 2013
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos   +6 more
doaj   +1 more source

Drusen complement components C3a and C5a promote choroidal neovascularization [PDF]

Proceedings of the National Academy of Sciences, 2006
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the presence of drusen, extracellular deposits that accumulate beneath the retinal pigmented epithelium.
Miho, Nozaki, Brian J, Raisler, Eiji, Sakurai, J Vidya, Sarma, Scott R, Barnum, John D, Lambris, Yali, Chen, Kang, Zhang, Balamurali K, Ambati, Judit Z, Baffi, Jayakrishna, Ambati   +10 more
openaire   +2 more sources

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury [PDF]

Kidney International, 2011
To prevent injury to host tissues, complement activation is regulated by a number of plasma and membrane-associated proteins, most of which limit C3 and C5 activation. An influx of circulating C3 from a syngeneic host into donor kidneys deficient in Crry (a membrane protein that reduces C3 convertase activity) causes spontaneous complement activation ...
Bao, Lihua, Wang, Ying, Haas, Mark, Quigg, Richard J.   +3 more
openaire   +2 more sources

Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]

, 2014
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W., Gracon, Adam, Gu, Hongmei, Mickler, Elizabeth A., Sandusky, George E., Vittal, Ragini, Weber, Daniel J., Wilkes, David S., Woodruff, Trent   +8 more
core   +1 more source

Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]

Scandinavian Journal of Immunology, 2008
AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker, V R, Savely, N C, Motanya, P C, Giclas   +3 more
openaire   +2 more sources

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Complement activation and its prognostic role in post-cardiac arrest patients [PDF]

, 2014
Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood.
Bisschops, Bottiger, Cervera, Dunkelberger, Fust, Gombos, Gorsuch, Kohler, Lindsberg, Matsushita, Mocco, Oddo, Pedersen, Prohaszka, Shinozaki, Szeplaki, Turner, Wojtczak-Soska   +17 more
core   +1 more source