Results 31 to 40 of about 15,469 (215)
The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
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Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]
PLoS ONE, 2012 The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet +11 more
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Efficient chemical synthesis of human complement protein C3a [PDF]
Chemical Communications, 2013 We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was fully active and its crystal structure at 2.1 Å resolution showed 3 helices and a C-terminal turn ...
Ghassemian, Artin +7 more
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Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity [PDF]
, 2020 Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157.
Hamidon, Johan K +17 more
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Frontiers in Immunology, 2021 Complement component 3 fragment C3a is an anaphylatoxin involved in promoting cellular responses important in immune response and host defense. Its receptor (C3a receptor, C3aR) is distributed on the plasma membrane; however, lysosomal localization in ...
Masaaki Ishii +5 more
doaj +1 more source
Scientific Reports, 2021 We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka +13 more
doaj +1 more source
Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor [PDF]
Bioconjugate Chemistry, 2017 Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative new ligands in competition with native ligand labeled with a radioisotope of finite lifetime.
Aline Dantas de Araujo +6 more
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The Role of Complement in Tumors [PDF]
, 2020 The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.
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Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression [PDF]
, 2021 Introduction: We recently performed a combined analysis of publicly available proteomic studies of aqueous humor (AH) of patients with primary open angle glaucoma (POAG).
C.A.B. Webers +7 more
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Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +17 more
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