Results 51 to 60 of about 400,071 (226)

The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]

PLoS ONE, 2013
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos   +6 more
doaj   +1 more source

Drusen complement components C3a and C5a promote choroidal neovascularization [PDF]

Proceedings of the National Academy of Sciences, 2006
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the presence of drusen, extracellular deposits that accumulate beneath the retinal pigmented epithelium.
Miho, Nozaki, Brian J, Raisler, Eiji, Sakurai, J Vidya, Sarma, Scott R, Barnum, John D, Lambris, Yali, Chen, Kang, Zhang, Balamurali K, Ambati, Judit Z, Baffi, Jayakrishna, Ambati   +10 more
openaire   +2 more sources

Astrocyte Responses to Complement Peptide C3a are Highly Context-Dependent

Neurochemical Research, 2022
AbstractAstrocytes perform a range of homeostatic and regulatory tasks that are critical for normal functioning of the central nervous system. In response to an injury or disease, astrocytes undergo a pronounced transformation into a reactive state that involves changes in the expression of many genes and dramatically changes astrocyte morphology and ...
Pekna, Marcela, Siqin, Sumen, de Pablo, Yolanda, Stokowska, Anna, Naluai, Åsa Torinsson, Pekny, Milos   +5 more
openaire   +2 more sources

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Activation of complement by hemodialysis membranes: Polyacrylonitrile binds more C3a than cuprophan [PDF]

, 1990
Activation of complement by hemodialysis membranes: Polyacrylonitrile binds more C3a than cuprophan. Conventionally, complement activation by hemodialysis membranes has been determined by measuring fluid phase C3a.
Janatova, Jarmila, Cheung, Alfred K., Parker, Charles J., Wilcox, Linda A.   +3 more
core   +1 more source

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
doaj   +1 more source

Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD, Yasuharu Oguchi, MD, PhD, Tomoko Omori, PhD, Akihito Kasai, MD, Masashi Ogasawara, MD, Yukinori Sugano, MD, PhD, Kanako Itagaki, MD, Akira Ojima, MD, PhD, Yumi Ishida, Takeshi Machida, PhD, Hideharu Sekine, MD, PhD, Tetsuju Sekiryu, MD, PhD   +11 more
doaj   +1 more source

Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression

, 2021
Introduction: We recently performed a combined analysis of publicly available proteomic studies of aqueous humor (AH) of patients with primary open angle glaucoma (POAG).
C.A.B. Webers, Gorgels, T.G.M.F., H.J.M. Beckers, Beckers, H.J.M., Hubens, W.H.G., T.G.M.F. Gorgels, W.H.G. Hubens, Webers, C.A.B.   +7 more
core   +1 more source

C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

Journal of Innate Immunity, 2021
To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with ...
Susanne Mommert, Lisa Doenni, Phillip Szudybill, Christoph Zoeller, Frerk Hinnerk Beyer, Thomas Werfel   +5 more
doaj   +1 more source

The Role of Complement in Tumors

, 2020
The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.

core   +1 more source