Results 51 to 60 of about 15,469 (215)

C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

Journal of Innate Immunity, 2021
To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with ...
Susanne Mommert, Lisa Doenni, Phillip Szudybill, Christoph Zoeller, Frerk Hinnerk Beyer, Thomas Werfel   +5 more
doaj   +1 more source

Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. [PDF]

Nat Commun, 2017
Regeneration of skeletal muscle following injury is accompanied by transient inflammation. Here we show that complement is activated in skeletal muscle injury and plays a key role during regeneration. Genetic ablation of complement C3 or its inactivation
Zhang C, Wang C, Li Y, Miwa T, Liu C, Cui W, Song WC, Du J.   +7 more
europepmc   +2 more sources

Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD, Yasuharu Oguchi, MD, PhD, Tomoko Omori, PhD, Akihito Kasai, MD, Masashi Ogasawara, MD, Yukinori Sugano, MD, PhD, Kanako Itagaki, MD, Akira Ojima, MD, PhD, Yumi Ishida, Takeshi Machida, PhD, Hideharu Sekine, MD, PhD, Tetsuju Sekiryu, MD, PhD   +11 more
doaj   +1 more source

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor [PDF]

, 2016
Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR.
Conor C. G. Scully (1724716), David P. Fairlie (180958), Jade S. Blakeney (2286424), Robert C. Reid (1436797), Ranee Singh (1730740), Giovanni Abbenante (2245186), Huy N. Hoang (395310)   +6 more
core   +1 more source

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Journal of Neuroinflammation, 2010
Background Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
Tsokos George C, Simovic Milomir, Dalle Lucca Shawn L, Li Yansong, Wang Ying, Dalle Lucca Jurandir J   +5 more
doaj   +1 more source

Complement activation products in liquid stored plasma and C3a kinetics after transfusion of autologous plasma. [PDF]

, 2011
Background and Objectives Keeping a small stock of liquid plasma readily available for transfusion is common practise in Sweden. We report data on complement activation markers in plasma components during storage in the liquid state and the kinetics of ...
Nilsson Ekdahl, Kristina,, Knutson, E F, O. Berséus, Norda, Rut, Norda, Rut,, Schött, U, Åkerblom, Olof,, K. N. Ekdahl, Åkerblom, O, Schött, Ulf,, Norda, R, et F. Knutson, Stegmayr, Bernd G.,, Schott, U., Knutson, F., Nilsson, B., Nilsson, Bo, Knutson, Folke,, Stegmayr, Bernd,, Åkerblom, Olof, Akerblom, O., Schött, Ulf, Knutson, Folke, B. Nilsson, Berseus, O., Ekdahl, K. N., Stegmayr, B G, Nilsson, Bo,, Ekdahl, K N, Norda, R., B. G. Stegmayr, R. Norda, Nilsson, B, Berséus, O, U. Schött, Berséus, Olof, Lund University., Berseus, Olof,, Stegmayr, Bernd, O. Åkerblom   +39 more
core   +1 more source

Biomarkers of the Complement System Activation (C3a, C5a, sC5b-9) in Serum of Patients before and after Liver Transplantation

Biomedicines, 2023
The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska, Ewa Ostrycharz, Natalia Maria Serwin, Łukasz Nazarewski, Elżbieta Cecerska-Heryć, Marta Poręcka, Paweł Rykowski, Radosław Pietrzak, Krzysztof Zieniewicz, Aldona Siennicka, Beata Hukowska-Szematowicz, Barbara Dołęgowska   +11 more
doaj   +1 more source

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia [PDF]

, 2016
Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability ...
Morán, Javier, Tulen Pekny, Barnum, Scott R, Pascoe, Michaela C,, Atkins, Alison L, Scott R. Barnum, Stokowska, Anna,, Michaela C. Pascoe, Atkins, Alison L,, Pascoe, Michaela, Stokowska, Anna, Barnum, Scott R,, Nilsson, Jonas A,, Alison L. Atkins, Dragunow, Mike,, Javier Morán, Linda Bulmer, Pekna, Marcela, Nilsson, Jonas A, Bulmer, Linda,, Wetsel, Rick A,, Wetsel, Rick A, Dragunow, Mike, Pascoe, Michaela C.,, Pekny, Tulen, Bulmer, Linda, Pekna, Marcela,, Pekny, Tulen,, Jonas A. Nilsson, Morán, Javier,, Anna Stokowska, Marcela Pekna, Mike Dragunow, Rick A. Wetsel   +33 more
core   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source