Results 51 to 60 of about 26,149 (232)

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Barthel, Diana, Böhm, Sascha, Elsen, Jean van den, Koch, Tina K., Kraiczy, Peter, Reuter, Michael, Skerka, Christine, Zipfel, Peter F.   +7 more
core   +5 more sources

Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]

, 1982
Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T ...
Goetzl, EJ, Payan, DG, Trentham, DE
core  

Preservation of Antimicrobial Properties of Complement Peptide C3a, from Invertebrates to Humans [PDF]

Journal of Biological Chemistry, 2007
The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences showed that, in particular in vertebrate C3a, crucial structural determinants governing antimicrobial ...
Pasupuleti, Mukesh, Walse, Bjorn, Nordahl, Emma, Mörgelin, Matthias, Malmsten, Martin, Schmidtchen, Artur   +5 more
openaire   +3 more sources

Elephant‐Skin‐Inspired Porous Cementitious Tiles with Programmable Crack Networks for Passive Cooling

Advanced Materials, EarlyView.
Elephant‐skin‐inspired crack networks are programmed in porous diatomaceous earth (DE)‐cement composites using substrate‐guided, stress‐concentration induced fracture. The resulting crack lattices act as capillary conduits that redistribute water, while the porous matrix stores moisture.
Qingya Huang, Kun‐Hao Yu, Ji Yoon Bae, Yunchan Lee, Dorit Aviv, Shu Yang   +5 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. [PDF]

PLoS ONE, 2017
The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood.
Xue-Jun Zhao, Timothy M Larkin, Molly A Lauver, Saif Ahmad, Andrew F Ducruet   +4 more
doaj   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Dextran sulfate activates the contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C., Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kohl, Jacek, Siebeck, Matthias, Spannagl, Michael, Spies, Bernd   +7 more
core   +4 more sources

PET radiotracer targeting the complement C3a receptor

Nuclear Medicine and Biology
Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of this study was to develop a PET radiotracer targeting the C3a receptor (C3aR) of the complement system.C3aR radiotracer [18F]1 was synthesized in ...
Naik, Ravi, Cha, Hyojin, Shen, Fangyi, Das, Deepankar, Hall, Andrew, Holt, Daniel, Mathews, William B., Dannals, Robert F., Minn, Il, Pletnikov, Mikhail, Pomper, Martin G., Horti, Andrew G.   +11 more
openaire   +3 more sources

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source