Results 71 to 80 of about 15,469 (215)

Antifungal activity of C3a and C3a-derived peptides against Candida [PDF]

, 2007
Antimicrobial peptides are generated during activation of the complement system [Nordahl et al. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:16879-16884].
Ringstad, Lovisa,, Sonesson, Andreas, Ringstad, Lovisa, Malmsten, Martin, Schmidtchen, Artur, Malmsten, Martin,, Mörgelin, M, Andersson Nordahl, Emma, Mörgelin, Matthias, Nordahl, Emma, Sonesson, A, Schmidtchen, A   +11 more
core   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage [PDF]

, 2007
OBJECTIVE: Studies have documented an inflammatory response in the circulating plasma and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage (aSAH). In particular, early upregulation of several complement proteins, including C3a, C4a,
Mack, William J, Albert, Eli J, Hickman, Zachary L, Kellner, Christopher P, Garrett, Matthew C, Ducruet, Andrew F, Mocco, J, Connolly, E Sander   +7 more
core   +1 more source

Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID. [PDF]

, 2022
Vascular contributions to cognitive impairment and dementia (VCID) secondary to chronic mild-moderate cerebral ischemia underlie a significant percentage of cases of dementia.
Ahmad, Saif, Ducruet, Andrew F, Bhatia, Kanchan, Fuentes, Alberto, Turner, Gregory H, Mufson, Elliott J, Ahmad, Abdullah S, Khan, Mohammad Badruzzaman, Yin, Junxiang, Nadeem, Muhammad, Miller, Karis, Kindelin, Adam, Preul, Mark C, Waters, Michael F   +13 more
core   +1 more source

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention. [PDF]

PLoS ONE, 2018
The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been ...
Nehemiah Zewde, Dimitrios Morikis
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy?

Biology
Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins, Valeria Molina, Stanley Wiernicki, Kenneth Okwuegbe, Xiaodong Feng, Hongbin Wang   +5 more
doaj   +1 more source

Potent Heterocyclic Ligands for Human Complement C3a Receptor [PDF]

, 2016
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases.
Junxian Lim (1436800), Johan K. Hamidon (1730743), Martin J. Stoermer (777268), David P. Fairlie (180958), Mei-Kwan Yau (1436788), Robert C. Reid (1436797), Ranee Singh (1730740)   +6 more
core   +1 more source

Quadruplex Bioactive FAND for Treating Acute Liver Failure Induced by Acetaminophen or Hepatectomy

Exploration, EarlyView.
This work developed a bioactive quadruplex FANDHP@FuEVs with intrinsic inflammation‐targeting properties of M2‐EVs and MSC‐EVs, harnessing the synergistic biological activities by leveraging four natural active components—M2‐EVs, MSC‐EVs, HGF, and PPC—to deliver pleiotropic therapies, including antioxidant, anti‐inflammatory, pro‐regenerative, and M1 ...
Meng Sun, Fang Fang, Juan Liu, Yueyun Fan, Sa Wang, Chuang Zhang, Weiyu Li, Zhengyang Quan, Dongxu Zhao, Min Hu, Jinfeng Zhang   +10 more
wiley   +1 more source