Results 61 to 70 of about 15,469 (215)

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. [PDF]

PLoS ONE, 2017
The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood.
Xue-Jun Zhao, Timothy M Larkin, Molly A Lauver, Saif Ahmad, Andrew F Ducruet   +4 more
doaj   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

PET radiotracer targeting the complement C3a receptor

Nuclear Medicine and Biology
Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of this study was to develop a PET radiotracer targeting the C3a receptor (C3aR) of the complement system.C3aR radiotracer [18F]1 was synthesized in ...
Naik, Ravi, Cha, Hyojin, Shen, Fangyi, Das, Deepankar, Hall, Andrew, Holt, Daniel, Mathews, William B., Dannals, Robert F., Minn, Il, Pletnikov, Mikhail, Pomper, Martin G., Horti, Andrew G.   +11 more
openaire   +3 more sources

Complement C3a Mobilizes Dental Pulp Stem Cells and Specifically Guides Pulp Fibroblast Recruitment [PDF]

, 2016
International audienceIntroduction: Complement activation is considered as a major mechanism in innate immunity. Although it is mainly involved in initiating inflammation, recent data reported its involvement in other processes such as tissue ...
Charlotte Jeanneau, Patrick Laurent, Imad About, Jeanneau, Charlotte, Rombouts, Charlotte, Laurent, Patrick, About, Imad, Pierre Rufas, Charlotte Rombouts, Rufas, Pierre   +9 more
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a [PDF]

, 2014
The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury.
Monk, Peter N., Kieslich, Chris A., Floudas, Christodoulos A., Cooper, Matthew A, Branchett, W., Bellows-Peterson, Meghan L., Smadbeck, James, Monk, P.N., Bellows-Peterson, Meghan L, Croker, Daniel E, Cooper, M.A., Woodruff, Trent M., Smadbeck, J., Kieslich, Chris A, Croker, Daniel E., Woodruff, Trent M, Morikis, D., Bellows-Peterson, M.L., Croker, D.E., Woodruff, T.M., Floudas, Christodoulos A, Floudas, C.A., Monk, Peter N, Kieslich, C.A., Halai, Reena, Morikis, Dimitrios, Branchett, Will, Cooper, Matthew A., Halai, R.   +28 more
core   +1 more source

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist

Frontiers in Pharmacology, 2021
Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff   +4 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14 [PDF]

The Journal of Immunology, 2013
Abstract Activation of the complement system is primarily initiated by pathogen- and damage-associated molecular patterns on cellular surfaces. However, there is increasing evidence for direct activation of individual complement components by extrinsic proteinases as part of an intricate crosstalk between physiological effector systems ...
Katerina, Oikonomopoulou, Robert A, DeAngelis, Hui, Chen, Eleftherios P, Diamandis, Morley D, Hollenberg, Daniel, Ricklin, John D, Lambris   +6 more
openaire   +2 more sources

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source