Results 81 to 90 of about 15,469 (215)

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth [PDF]

, 2015
The complement activation product C3a is often described as a proinflammatory mediator, alongside its downstream cousin, C5a. However, emerging studies show that C3a has several anti-inflammatory facets in vivo.
Coulthard, Liam G., Woodruff, Trent M.
core   +1 more source

Early Elevations of the Complement Activation Fragment C3a and Adverse Pregnancy Outcomes [PDF]

Obstetrics & Gynecology, 2011
To estimate whether elevations of complement C3a early in pregnancy are predictive of the subsequent development of adverse pregnancy outcomes.A plasma sample was obtained from each enrolled pregnant woman before 20 weeks of gestation. The cohort (n=1,002) was evaluated for the development of adverse pregnancy outcomes defined as hypertensive diseases ...
Anne M, Lynch, Ronald S, Gibbs, James R, Murphy, Patricia C, Giclas, Jane E, Salmon, V Michael, Holers   +5 more
openaire   +2 more sources

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Comparison of Porcine Hepatocytes with Human Hepatoma (C3A) Cells for Use in a Bioartificial Liver Support System

Cell Transplantation, 1998
Cells from primary porcine hepatocytes (PPH) and the immortalized human hepatoma cell line C3A are both used in bioartificial liver support systems (BALSS).
Lisheng Wang, Junhong Sun, Li Li, Douglas Mears, Margret Horvat, AG Ross Sheil   +5 more
doaj   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

A Multicenter, Open‐Label, Phase 2 Trial Comparing Crizanlizumab Combined With Standard Therapy to Standard Therapy Alone on Renal Function in Patients With Sickle Cell Nephropathy (STEADFAST)

American Journal of Hematology, EarlyView.
Kenneth I. Ataga, Pablo Bartolucci, Santosh L. Saraf, Vimal K. Derebail, Adlette Inati, Jeffrey D. Lebensburger, Laurie DeBonnett, Rodolfo D. Cancado, Claire C. Sharpe   +8 more
wiley   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Erythropoietin Effect on Complement Activation in Chronic Kidney Disease

Biomedicines
The complement system is an important part of innate immunity. Despite its known protective role, the complement system may contribute to increased inflammation and tissue injury in cases where its balanced activation is disrupted.
Virginia Athanasiadou, Kleio Ampelakiotou, Eirini Grigoriou, Katherina Psarra, Alexandra Tsirogianni, Serena Valsami, Theodoros Pittaras, Eirini Grapsa, Maria G. Detsika   +8 more
doaj   +1 more source

Tracking Summer Greenland Blocking: The Upstream Pathway Shapes Historical Extremes and Future Change

International Journal of Climatology, EarlyView.
This study investigates summer Greenland atmospheric blocking using the Lagrangian tracking Python package blocktrack applied to ERA5 reanalysis and CMIP6 models. Two types of blocks—upstream (Northern Canada origin) and retrograding (Northern Atlantic origin)—are distinguished, with upstream blocks driving recent observed frequency increasing trends ...
Michele Filippucci, Jacob Maddison, Simona Bordoni   +2 more
wiley   +1 more source

The Complement C3a And C3a Receptor Pathway Indiabetic Patients With Entamobra Histolytica, Cryptospridium Parvum

International Journal of Environmental Sciences
Cryptosporidium parvum and Entamoeba histolytica are significant protozoan parasites that adversely impact human health. The infection rate of these parasites among diabetic patients was recorded at 18.33%. However, the mechanisms underlying host-parasite interactions remain poorly understood.
Bafreen Mohamad Raza, Naema Ali Ahmed, Sahlah Kh. Abbas   +2 more
openaire   +1 more source