Results 81 to 90 of about 400,071 (226)

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention. [PDF]

PLoS ONE, 2018
The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been ...
Nehemiah Zewde, Dimitrios Morikis
doaj   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor

, 2016
Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR.
Conor C. G. Scully (1724716), David P. Fairlie (180958), Jade S. Blakeney (2286424), Robert C. Reid (1436797), Ranee Singh (1730740), Giovanni Abbenante (2245186), Huy N. Hoang (395310)   +6 more
core   +1 more source

Complement activation products in liquid stored plasma and C3a kinetics after transfusion of autologous plasma.

, 2011
Background and Objectives Keeping a small stock of liquid plasma readily available for transfusion is common practise in Sweden. We report data on complement activation markers in plasma components during storage in the liquid state and the kinetics of ...
Nilsson Ekdahl, Kristina,, Knutson, E F, O. Berséus, Norda, Rut, Norda, Rut,, Schött, U, Åkerblom, Olof,, K. N. Ekdahl, Åkerblom, O, Schött, Ulf,, Norda, R, et F. Knutson, Stegmayr, Bernd G.,, Schott, U., Knutson, F., Nilsson, B., Nilsson, Bo, Knutson, Folke,, Stegmayr, Bernd,, Åkerblom, Olof, Akerblom, O., Schött, Ulf, Knutson, Folke, B. Nilsson, Berseus, O., Ekdahl, K. N., Stegmayr, B G, Nilsson, Bo,, Ekdahl, K N, Norda, R., B. G. Stegmayr, R. Norda, Nilsson, B, Berséus, O, U. Schött, Berséus, Olof, Lund University., Berseus, Olof,, Stegmayr, Bernd, O. Åkerblom   +39 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

, 2016
Ischaemic stroke induces endogenous repair processes that include proliferation and differentiation of neural stem cells and extensive rewiring of the remaining neural connections, yet about 50% of stroke survivors live with severe long-term disability ...
Morán, Javier, Tulen Pekny, Barnum, Scott R, Pascoe, Michaela C,, Atkins, Alison L, Scott R. Barnum, Stokowska, Anna,, Michaela C. Pascoe, Atkins, Alison L,, Pascoe, Michaela, Stokowska, Anna, Barnum, Scott R,, Nilsson, Jonas A,, Alison L. Atkins, Dragunow, Mike,, Javier Morán, Linda Bulmer, Pekna, Marcela, Nilsson, Jonas A, Bulmer, Linda,, Wetsel, Rick A,, Wetsel, Rick A, Dragunow, Mike, Pascoe, Michaela C.,, Pekny, Tulen, Bulmer, Linda, Pekna, Marcela,, Pekny, Tulen,, Jonas A. Nilsson, Morán, Javier,, Anna Stokowska, Marcela Pekna, Mike Dragunow, Rick A. Wetsel   +33 more
core   +1 more source