Results 101 to 110 of about 400,071 (226)

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

open access: yesInternational Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed   +3 more
doaj   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

open access: yesVIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf   +5 more
wiley   +1 more source

Indoor microbial exposure increases complement component C3a and C-reactive protein concentrations in serum

open access: yesHeliyon
Indoor exposure to microbial growth, caused by moisture damage, has been an established health risk for several decades. It is likely that a damp indoor environment contains biological pollutants that trigger both the innate and adaptive branches of the ...
Outi Karhuvaara   +4 more
doaj   +1 more source

Elements on the move: How ungulate migration expands Alpine biogeochemical footprints

open access: yesJournal of Animal Ecology, EarlyView.
Using a spatially explicit model parameterized with GPS telemetry, we show that migratory and resident red deer play distinct roles in nitrogen redistribution across alpine landscapes. Migrants uniquely transport nitrogen upslope and up elevation, linking ecosystem element pools and revealing how the loss of migration alters large‐scale ecosystem ...
Kristy M. Ferraro   +10 more
wiley   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

open access: yesIntegrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv   +4 more
wiley   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai   +4 more
wiley   +1 more source

Clinical significance of circulating immune complexes and components of the blood complement system in viral meningitis in children

open access: yesЛечащий Врач
Background. Neuroinfections are one of the global medical and social problems of pediatrics, due to the high incidence of neurological complications that affect the further development of the child.Objective. To establish the clinical significance of the
G. A. Kharchenko, O. G. Kimirilova
doaj   +1 more source

Enzymatic Reactions and Detection of C3 Cleavage Fragments

open access: yesBio-Protocol, 2014
The complement component C3 is the major effector molecule of the complement system. C3 circulates in the blood and interstitial fluids as pro-enzyme and is activated by enzymatic cleavage into a C3a portion, a classic anaphylatoxin that functions as ...
Claudia Kemper, Martin Kolev
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

open access: yesAllergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan   +5 more
wiley   +1 more source

Early plasma complement C3a levels correlate with functional outcome after aneurysmal subarachnoid hemorrhage

open access: yes, 2007
OBJECTIVE: Studies have documented an inflammatory response in the circulating plasma and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage (aSAH). In particular, early upregulation of several complement proteins, including C3a, C4a,
Mack, William J   +7 more
core   +1 more source

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