Results 101 to 110 of about 15,469 (215)

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

open access: yesAllergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama   +16 more
wiley   +1 more source

Enzymatic Reactions and Detection of C3 Cleavage Fragments

open access: yesBio-Protocol, 2014
The complement component C3 is the major effector molecule of the complement system. C3 circulates in the blood and interstitial fluids as pro-enzyme and is activated by enzymatic cleavage into a C3a portion, a classic anaphylatoxin that functions as ...
Claudia Kemper, Martin Kolev
doaj   +1 more source

Antifungal Effects of Complement Peptide C3a on Candida glabrata [PDF]

open access: yes, 2016
Candida glabrata is a human opportunistic pathogen which causes superficial and life-threatening systemic infections. Over the last three decades, the number of candidiasis cases attributed to C. glabrata has risen at an alarming rate.
Dinh, Jessica
core  

Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome [PDF]

open access: yes, 1990
SUMMARY In vivo and in vitro studies have shown that complement activation plays an important role in the pathogenesis of the adult respiratory distress syndrome (ARDS). In a prospective study of polytrauma patients at risk of ARDS (n= 38)
G ZILOW   +3 more
core   +1 more source

Role of Complement Anaphylatoxins (C3a and C5a) in Lymphoma: A Systematic Review

open access: yesCureus
Tumor cell survival, growth, and proliferation are related to the interactions between tumor cells and immune cells. Anaphylatoxins C3a and C5a seem to be involved in these cell-to-cell interactions. The aim of this study is to investigate whether the increase of C3a and/or C5a levels induces the proliferation of lymphoma cells.
Skarentzos, Konstantinos   +3 more
openaire   +3 more sources

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

open access: yesAllergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan   +5 more
wiley   +1 more source

Clinical significance of circulating immune complexes and components of the blood complement system in viral meningitis in children

open access: yesЛечащий Врач
Background. Neuroinfections are one of the global medical and social problems of pediatrics, due to the high incidence of neurological complications that affect the further development of the child.Objective. To establish the clinical significance of the
G. A. Kharchenko, O. G. Kimirilova
doaj   +1 more source

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi   +13 more
wiley   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

Role of the Complement Components C5 and C3a in a Mouse Model of Myocardial Ischemia and Reperfusion Injury [PDF]

open access: yes, 2010
Objective: Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury.
Busche, MN   +3 more
core   +1 more source

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