Results 121 to 130 of about 26,149 (232)

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent

Molecular Vision, 2019
Purpose: Smoking and the incidence of age-related macular degeneration (AMD) have been linked to an overactive complement system. Here, we examined in a retrospective cohort study whether AMD-associated single nucleotide polymorphisms (SNPs), smoking ...
Bärbel Rohrer, Ashley Frazer-Abel, Anthony Leonard, Rinki Ratnapriya, Tyson Ward, Alexandra Pietraszkiewicz, Elizabeth O’Quinn, Katherine Adams, Anand Swaroop, Bethany Jacobs Wolf   +9 more
doaj  

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity. [PDF]

J Clin Invest, 2023
Stokowska A, Aswendt M, Zucha D, Lohmann S, Wieters F, Morán Suarez J, Atkins AL, Li Y, Miteva M, Lewin J, Wiedermann D, Diedenhofen M, Torinsson Naluai Å, Abaffy P, Valihrach L, Kubista M, Hoehn M, Pekny M, Pekna M.   +18 more
europepmc   +1 more source

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, Volume 37, Issue 3, Page 375-385, June 2026.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage. [PDF]

Front Neurosci, 2022
Wang S, Du L, Yuan S, Peng GH.
europepmc   +1 more source

Synthesis, Crystal Structure, and Optoelectronic Properties of [(n‐/tert‐C4H9)S(CH3)2]PbI3

European Journal of Inorganic Chemistry, Volume 29, Issue 15, 20 May 2026.
Reaction of two isomers of butyldimethylsulfonium cation with PbI2 using solid‐state and solution methods yielded the corresponding organic/inorganic hybrid compounds with high humidity tolerance and 1D crystal structures of [n‐C4H9S(CH3)2]PbI3 and [tert‐C4H9S(CH3)2]PbI3.
Ioannis Koutsoumpogeras, Nikolaos Tsoureas, Nagia S. Tagiara, Ioannis Koutselas, Andreas Kaltzoglou   +4 more
wiley   +1 more source

External Vibrations on Early‐Age Concrete: A Review

Engineering Reports, Volume 8, Issue 5, May 2026.
Scientific illustration of external vibration, their influencing properties and effects, possible outcomes and measures adapted. ABSTRACT Early‐age concrete exhibits limited mechanical strength, making it highly susceptible to external disturbances such as vibrations from construction activities, traffic, or nearby machinery which can disrupt internal ...
Parvathy Kizhakkiniyedath Mohanan, Sylvia Keßler   +1 more
wiley   +1 more source

“Reactions in Leprosy: Updated Insights Into Pathophysiology, Clinical Spectrum, and Therapeutic Approaches—A Narrative Review”

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Reaction in leprosy is an immune‐mediated acute inflammatory episodes that occur in the natural course of Hansen's disease. Reaction can occur before, during, or after starting multidrug therapy and is a major cause of nerve damage, morbidity, and disability in affected individuals.
Bhaskar Gupta, Manesha Singh, Mohamad Goldust, Kinnor Das, Surajit Gorai, Prajwal Pudasaini, Seema Sitaula, Achyut Pokhrel, Esna Thapa, Sunil Jaiswal   +9 more
wiley   +1 more source

Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity

Experimental Biology and Medicine
Investigations on some innate immunity proteins can yield misleading information, as investigators often rely on static measurements and assume a direct correlation to function. As protein function is often not directly proportional to protein abundance,
Douglas D. Fraser, Douglas D. Fraser, Swapan Roy, Matt Kuruc, Maritza Quintero, Logan R. Van Nynatten, Gediminas Cepinskas, Gediminas Cepinskas, Haiyan Zheng, Amenah Soherwardy, Devjit Roy   +10 more
doaj   +1 more source