Results 111 to 120 of about 400,071 (226)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

C3a is made by proximal tubular HK-2 cells and activates them via the C3a receptor [PDF]

, 1999
C3a is made by proximal tubular HK-2 cells and activates them via the C3a receptor.BackgroundSome individual components of complement are synthesized by the kidney.
Pussell, Bruce A., Peake, Philip W., O'Grady, Sue, Sue O'Grady, John A. Charlesworth, Philip W. Peake, Bruce A. Pussell, Charlesworth, John A.   +7 more
core   +1 more source

The Complement System in Post‐Transplant Kidney Injury

Organ Medicine, EarlyView.
Mengsi Hu
wiley   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Potent Heterocyclic Ligands for Human Complement C3a Receptor

, 2016
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases.
Junxian Lim (1436800), Johan K. Hamidon (1730743), Martin J. Stoermer (777268), David P. Fairlie (180958), Mei-Kwan Yau (1436788), Robert C. Reid (1436797), Ranee Singh (1730740)   +6 more
core   +1 more source

C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.

PLoS ONE, 2014
ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li, Qinghua Yin, Xi Tang, Lin Bai, Jie Zhang, Shenju Gou, Hongping Zhu, Jingqiu Cheng, Ping Fu, Fang Liu   +9 more
doaj   +1 more source

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth

, 2015
The complement activation product C3a is often described as a proinflammatory mediator, alongside its downstream cousin, C5a. However, emerging studies show that C3a has several anti-inflammatory facets in vivo.
Coulthard, Liam G., Woodruff, Trent M.
core   +1 more source

Role of Complement Anaphylatoxins (C3a and C5a) in Lymphoma: A Systematic Review

Cureus
Tumor cell survival, growth, and proliferation are related to the interactions between tumor cells and immune cells. Anaphylatoxins C3a and C5a seem to be involved in these cell-to-cell interactions. The aim of this study is to investigate whether the increase of C3a and/or C5a levels induces the proliferation of lymphoma cells.
Skarentzos, Konstantinos, Vryttia, Pinelopi, Papageorgiou, Sotiris, Foukas, Periklis   +3 more
openaire   +3 more sources

Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response

Journal of Neuroinflammation
Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +1 more source

Acidosis activates complement system in vitro

Mediators of Inflammation, 1998
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12)
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen   +5 more
doaj   +1 more source