Results 141 to 150 of about 400,071 (226)

Cracking the cytokine code in sickle cell disease: Immune‐informatics for precision inflammation mapping, risk prediction and therapeutic discovery

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Sickle cell disease inflammation emerges from interconnected cytokine networks. Immune‐informatics integrates multi‐omics, network biology and artificial intelligence to decode inflammatory signatures, predict complications and identify precision therapeutic targets. Abstract Background Sickle cell disease (SCD) is characterised by chronic inflammation
Emmanuel Ifeanyi Obeagu, Chukwuma J. Okafor   +1 more
wiley   +1 more source

Predictive value of complement activation fragments C3a and sC5b-9 for development of severe disease in patients with acute pancreatitis.

, 2003
BACKGROUND Complement activation has been shown to occur in patients with acute pancreatitis. However, the diagnostic potential of complement activation products in plasma for predicting severe disease remains unclear to date.
Büchler MW, Gloor B, Stahel PF, Schmidt OI, Uhl W, Müller CA   +5 more
core   +1 more source

Plastid Phylogenomics of Elatostemateae (Urticaceae): Insights Into Structural Variation and Phylogenetic Relationships

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study leverages complete plastid and nuclear ribosomal DNA sequences from 40 species to resolve the complex phylogeny and organellar genome evolution of the diverse plant tribe Elatostemateae. The analysis uncovered significant plastome structural variations, including novel inversions and a rare mitochondrial DNA integration event, and identified
Long‐Fei Fu, Zi‐Bing Xin, Chi Xiong, Fang Wen, Yi‐Gang Wei, Alexandre K. Monro   +5 more
wiley   +1 more source

Complement C3a Measurement [PDF]

, 2020
openaire   +1 more source

Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity

Experimental Biology and Medicine
Investigations on some innate immunity proteins can yield misleading information, as investigators often rely on static measurements and assume a direct correlation to function. As protein function is often not directly proportional to protein abundance,
Douglas D. Fraser, Douglas D. Fraser, Swapan Roy, Matt Kuruc, Maritza Quintero, Logan R. Van Nynatten, Gediminas Cepinskas, Gediminas Cepinskas, Haiyan Zheng, Amenah Soherwardy, Devjit Roy   +10 more
doaj   +1 more source

The Combination of Radiotherapy and Complement C3a Inhibition Potentiates Natural Killer cell Functions Against Pancreatic Cancer. [PDF]

Cancer Res Commun, 2022
Sodji QH, Nambiar DK, Viswanathan V, von Eyben R, Colburg D, Binkley MS, Li CG, Olcina MM, Chang DT, Le QT, Giaccia AJ.   +10 more
europepmc   +1 more source

C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Microglia‐derived migrasomes induce vascular endothelial pyroptosis through C1qc delivery, uncovering a novel mechanism of blood–brain barrier (BBB) disruption after intracerebral haemorrhage (ICH) and proposing a novel therapeutic strategy targeting extracellular vesicles (EVs).
Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi‐Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang, Xuemei Chen, Yating Wang, Qiong Yang, Moxin Wu, Xiaoping Yin, Junmin Wang, Jian Wang, Fuyou Guo   +17 more
wiley   +1 more source

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury. [PDF]

Neurochem Res, 2021
Pekna M, Stokowska A, Pekny M.
europepmc   +1 more source

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source