Results 161 to 170 of about 400,071 (226)

C3a targets the Hippo-YAP signaling pathway to promote Müller cells glial–mesenchymal transition in a high-glucose in vitro model

European Journal of Medical Research
Background Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, severely affecting the health and quality of life of individuals with diabetes.
Shuang Liu, Long Suo, Hongliang Chen, Qiankun Wang, Dongyuan Mao, Yuanyuan Cai, Bing Qin   +6 more
doaj   +1 more source

Understanding Surface Interfacial Phenomena During Tricalcium Silicate Dissolution From TEM and XRR

Journal of the American Ceramic Society, Volume 109, Issue 10, October 2026.
ABSTRACT Understanding the dissolution mechanism of tricalcium silicate (C3S) is essential for interpreting its reactivity in cementitious systems. While the dissolution mechanism of C3S has been considered to follow the classical leached‐layer model, the mechanism has also been proposed to occur through the coupled interfacial dissolution ...
Aidyn Tugelbayev, Hongyu Wang, David Jarret Wright, Jing Zhao, F. Marc Michel, Alexander S. Brand   +5 more
wiley   +1 more source

Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3776-3789, October 2026.
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang, Yiling Feng, Leiming You, Meimei Xu, Kristin Helwig, Riqing Li, Si Nian Char, Bing Yang, Reuben J. Peters   +8 more
wiley   +1 more source

Complement C3a receptor antagonism for ME/CFS neuroinflammation

Complement component 3a receptor (C3AR1) is activated by elevated C3a levels in ME/CFS patients, triggering microglial activation and neuroinflammation in brain regions controlling fatigue and cognitive function. C3AR1 antagonists like SB290157 or PMX205 could reduce complement-mediated neuroinflammation and improve central nervous system symptoms.
openaire   +2 more sources

Fibrinogen-like protein 2-complement C3 interaction exacerbates tubular inflammation in acute kidney injury by elevating complement C3a levels. [PDF]

Ren Fail
Wan W, Yang Q, Li J, Wu S, Hu X, Ruan Z, Wang R, Zhang Z, Geng X, Zhou Y, Lu Q, Ren H.   +11 more
europepmc   +1 more source

The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke. [PDF]

Cells
Akhter N, Lambay A, Almotairi R, Hamadi A, Bhatia K, Ahmad S, Ducruet AF.   +6 more
europepmc   +1 more source

Correction: Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma. [PDF]

J Transl Med
Jiang F, Zhang Y, Peng F, Liu H, Ding K, Cao P, Liu X, Li L, Liu Z, Fu R.   +9 more
europepmc   +1 more source

Structural insights into agonist-binding and activation of the human complement C3a receptor

, 2023
Yadav MK, Yadav R, Sarma P, Maharana J, Soni C, Saha S, Singh V, Ganguly M, Saha S, Khant HA, Banerjee R, Shukla AK, Gati C.   +12 more
europepmc   +1 more source

Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway. [PDF]

Neurosci Bull
Ding L, Li X, Guo Y, Zhou FQ, Deng DYB.
europepmc   +1 more source

Changes in complement C3a in the immunotherapy of advanced clear cell renal cell carcinoma. [PDF]

Transl Androl Urol
Zhang C, Yue W, Bian W, Wang J, Lucarelli G, Shao W, Dai X.   +6 more
europepmc   +1 more source