Results 41 to 50 of about 15,469 (215)

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E, Eridan Rocha-Ferreira, Eridan eRocha-Ferreira, Mariya eHristova, Hristova, M, Mariya Hristova   +5 more
core   +1 more source

Reduced order modeling and analysis of the human complement system. [PDF]

PLoS ONE, 2017
Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar, Wei Dai, Mason Minot, Rachel LeCover, Jeffrey D Varner   +4 more
doaj   +1 more source

Characterization of Synthetic C3a Analog Peptides on Human Eosinophils in Comparison to the Native Complement Component C3a [PDF]

The Journal of Immunology, 2000
Abstract The C3a anaphylatoxin is a potent proinflammatory mediator derived from the complement system inducing biologic effects of human eosinophils like Ca2+ transients and the activation of the respiratory burst. These findings support an important role for C3a in diseases typically associated with a peripheral blood or tissue ...
H, Petering, J, Köhl, A, Weyergraf, Y, Dulkys, D, Kimmig, R, Smolarski, A, Kapp, J, Elsner   +7 more
openaire   +2 more sources

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, J. C., Kohl, Jacek, M. Jochum, E. Fink, B. Spies, M. Siebeck, M. Spannagl, Siebeck, Matthias, J. C. Cheronis, Cheronis, John C., J. Kohl, H. Fritz, Spannagl, Michael, Jochum, Marianne, Spies, Bernd, Fritz, Hans, Fink, Edwin   +16 more
core   +1 more source

Complement activation contributes to perioperative neurocognitive disorders in mice

Journal of Neuroinflammation, 2018
Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu   +5 more
doaj   +1 more source

Drusen complement components C3a and C5a promote choroidal neovascularization [PDF]

Proceedings of the National Academy of Sciences, 2006
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the presence of drusen, extracellular deposits that accumulate beneath the retinal pigmented epithelium.
Miho, Nozaki, Brian J, Raisler, Eiji, Sakurai, J Vidya, Sarma, Scott R, Barnum, John D, Lambris, Yali, Chen, Kang, Zhang, Balamurali K, Ambati, Judit Z, Baffi, Jayakrishna, Ambati   +10 more
openaire   +2 more sources

Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]

Scandinavian Journal of Immunology, 2008
AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker, V R, Savely, N C, Motanya, P C, Giclas   +3 more
openaire   +2 more sources

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +1 more source

Activation of complement by hemodialysis membranes: Polyacrylonitrile binds more C3a than cuprophan [PDF]

, 1990
Activation of complement by hemodialysis membranes: Polyacrylonitrile binds more C3a than cuprophan. Conventionally, complement activation by hemodialysis membranes has been determined by measuring fluid phase C3a.
Janatova, Jarmila, Cheung, Alfred K., Parker, Charles J., Wilcox, Linda A.   +3 more
core   +1 more source

Astrocyte Responses to Complement Peptide C3a are Highly Context-Dependent

Neurochemical Research, 2022
AbstractAstrocytes perform a range of homeostatic and regulatory tasks that are critical for normal functioning of the central nervous system. In response to an injury or disease, astrocytes undergo a pronounced transformation into a reactive state that involves changes in the expression of many genes and dramatically changes astrocyte morphology and ...
Pekna, Marcela, Siqin, Sumen, de Pablo, Yolanda, Stokowska, Anna, Naluai, Åsa Torinsson, Pekny, Milos   +5 more
openaire   +2 more sources