Results 21 to 30 of about 400,071 (226)

Potent heterocyclic ligands for human complement C3a receptor

Journal of Medicinal Chemistry, 2014
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases.
Fairlie, David P., Stoermer, Martin J., Singh, Ranee, Hamidon, Johan K., Reid, Robert C., Yau, Mei-Kwan, Lim, Junxian   +6 more
core   +6 more sources

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a [PDF]

European Journal of Pharmacology, 2014
The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury.
Monk, Peter N., Kieslich, Chris A., Floudas, Christodoulos A., Cooper, Matthew A, Branchett, W., Bellows-Peterson, Meghan L., Smadbeck, James, Monk, P.N., Bellows-Peterson, Meghan L, Croker, Daniel E, Cooper, M.A., Woodruff, Trent M., Smadbeck, J., Kieslich, Chris A, Croker, Daniel E., Woodruff, Trent M, Morikis, D., Bellows-Peterson, M.L., Croker, D.E., Woodruff, T.M., Floudas, Christodoulos A, Floudas, C.A., Monk, Peter N, Kieslich, C.A., Halai, Reena, Morikis, Dimitrios, Branchett, Will, Cooper, Matthew A., Halai, R.   +28 more
core   +7 more sources

Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a

Free Radical Biology and Medicine, 2011
Oxidatively modified low-density lipoproteins (Ox-LDL) and complement anaphylatoxins C3a and C5a are colocalized in atherosclerotic lesions. Anaphylatoxin C3a also binds and breaks bacterial lipid membranes and phosphatidylcholine liposomes.
S Pauliina Turunen, Anna-Liisa Levonen-Harju, Outi Kummu   +2 more
exaly   +2 more sources

Comparison of serum C3, C3a, C4 levels between cataract patients with and without pseudoexfoliation and normal individuals [PDF]

BMC Ophthalmology
Background We aimed to compare serum complement C3, C3a, and C4 levels between cataract patients with and without pseudoexfoliation syndrome, and to compare these groups with the control group. Methods There were three different groups in the study.
Gülce Gökgöz Özışık, Hüseyin Kayadibi, İsmail Çağatay Çağlar, Hasan Basri Çakmak   +3 more
doaj   +2 more sources

Complement peptide C3a promotes astrocyte survival in response to ischemia

Molecular Neurobiology, 2016
Astrocytes are the most numerous cells in the central nervous system with a range of homeostatic and regulatory functions. Under normal conditions as well as after ischemia, astrocytes promote neuronal survival.
Shinjyo, Noriko,, Pekna, Marcela,, Pekny, Milos,, de Pablo, Yolanda,   +3 more
core   +3 more sources

PET radiotracer targeting the complement C3a receptor. [PDF]

Nucl Med Biol
Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of this study was to develop a PET radiotracer targeting the C3a receptor (C3aR) of the complement system.C3aR radiotracer [18F]1 was synthesized in ...
Naik R, Cha H, Shen F, Das D, Hall A, Holt D, Mathews WB, Dannals RF, Minn I, Pletnikov M, Pomper MG, Horti AG.   +11 more
europepmc   +4 more sources

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy. [PDF]

J Am Soc Nephrol, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Gao S, Cui Z, Zhao MH.
europepmc   +3 more sources

Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

Molecular Immunology, 2014
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are indispensable for T cell activation, stimulation of additional receptor pathways are also necessary for effector induction ...
Arije Ghannam, Christian Drouet, Claudia Kemper   +2 more
exaly   +2 more sources

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Journal of Translational Medicine, 2019
Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann   +4 more
doaj   +2 more sources

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources