Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity [PDF]
Journal of Translational Medicine, 2019 Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker +4 more
doaj +2 more sources
Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration. [PDF]
J Clin Invest, 2021 © 2021, American Society for Clinical Investigation. Vascular dysfunction resulting in compromised blood-brain barrier (BBB) integrity is evident in aging and disease.
Bhatia K +3 more
europepmc +2 more sources
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay [PDF]
, 2021 Enzyme-linked immunosorbent assay (ELISA) enables fast and simple quantification of analytes in the pico- to nanogram range in complex samples. Here, we describe an ELISA for the detection of porcine C3a as a marker for complement activation.
Skjeflo, Espen W., +23 more
core +1 more source
A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]
PeerJ, 2019 Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki +8 more
doaj +2 more sources
Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins
Frontiers in Immunology, 2021 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West +8 more
doaj +1 more source
Complement components C3a promoted tumor recurrence after liver transplantation [PDF]
, 2021 Introduction: Complement components are the keys regulators orchestrating many cellular responses including immunological responses. Increasing evidences showed complement components involved in many liver pathology.
Lo, CM +4 more
core +1 more source
Nociceptive sensitization by complement C5a and C3a in mouse [PDF]
Pain, 2010 Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang +5 more
openaire +2 more sources
Table_1_The association between serum complement C3a and severity in patients with community-acquired pneumonia.docx [PDF]
, 2023 BackgroundA few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure.
Hui Zhao (7395) +6 more
core +1 more source
BMC Psychiatry, 2022 Background Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation.
Xianmei Luo +5 more
doaj +1 more source
Cytolytic effects of the complement cleavage product, C3a [PDF]
British Journal of Cancer, 1976 Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b.
J, Ferluga +3 more
openaire +2 more sources