Results 11 to 20 of about 26,149 (232)

Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome [PDF]

Journal of Inflammation Research
Tianyan Chen,1,* Yawen Liu,2,* Yuan Liu,1 Nannan Hu,1 Yan Dai,1 Chuanlong Zhu,1 Yaping Han,1 Ke Jin,1 Jun Li1 1Department of Infectious Disease, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, People’s ...
Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J   +8 more
doaj   +2 more sources

Efficient chemical synthesis of human complement protein C3a [PDF]

Chemical Communications, 2013
We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was
Ames, Artin Ghassemian, Bajic, Bang, Bokisch, Ching-I Anderson Wang, Cianflone, Cook, Daffern, David P. Fairlie, Dawson, Elsner, Huber, Hugli, Kent, Klos, Mei-Kwan Yau, Morales, Mueller-Ortiz, Paques, Paul F. Alewood, Richard J. Lewis, Ricklin, Robert C. Reid, Schnölzer, Scully, Thomas Durek, Wilken   +27 more
core   +6 more sources

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +2 more sources

The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances [PDF]

Mediators of Inflammation
C3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR).
Xiangwei Bo, Mi Wang, Yang Liu, Yong Zhong   +3 more
doaj   +2 more sources

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy. [PDF]

J Am Soc Nephrol, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Gao S, Cui Z, Zhao MH.
europepmc   +3 more sources

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Nociceptive sensitization by complement C5a and C3a in mouse [PDF]

Pain, 2010
Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang, David J, Clark, Xiangqi, Li, Matthew S, Yorek, Yuriy M, Usachev, Timothy J, Brennan   +5 more
openaire   +2 more sources

Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma

BMC Psychiatry, 2022
Background Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation.
Xianmei Luo, Zeman Fang, Lingyun Lin, Haiyun Xu, Qingjun Huang, Handi Zhang   +5 more
doaj   +1 more source

Cytolytic effects of the complement cleavage product, C3a [PDF]

British Journal of Cancer, 1976
Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b.
J, Ferluga, H U, Schorlemmer, L C, Baptista, A C, Allison   +3 more
openaire   +2 more sources