Results 11 to 20 of about 400,071 (226)
ELISA of complement C3a in bronchoalveolar lavage fluid
Journal of Immunological Methods, 1992 Activated complement factors within the lung may induce several local biological effects. In order to investigate local complement activation we have developed non-competitive two-site ELISAs of C3a and total C3 in bronchoalveolar lavage fluid (BALF ...
H M Jansen +2 more
exaly +4 more sources
Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity [PDF]
Frontiers in Immunology, 2022 In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. In all pathways of complement activation, the pivotal step is conversion of the component C3 to C3b and C3a, which is responsible to eliminate the pathogen and opsonization.
Mo-Fei Li
exaly +4 more sources
Involvement of complement peptides C3a and C5a in osteoarthritis pathology
Peptides, 2022 Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society.
Schäfer, Nicole, Grässel, Susanne
core +3 more sources
The Role of Complement C3a Receptor in Stroke
NeuroMolecular Medicine, 2019 © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to
Saif Ahmad +7 more
core +3 more sources
Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury [PDF]
Kidney International, 2011 To prevent injury to host tissues, complement activation is regulated by a number of plasma and membrane-associated proteins, most of which limit C3 and C5 activation. An influx of circulating C3 from a syngeneic host into donor kidneys deficient in Crry
Lihua Bao +7 more
core +4 more sources
Anaphylatoxin C3a receptors in asthma [PDF]
Respiratory Research, 2005 The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils ...
Panettieri Reynold A, Ali Hydar
doaj +3 more sources
Elevated complement C3a in plasma from patients with severe acute asthma [PDF]
Journal of Allergy and Clinical Immunology, 2003 Complement component C3a, an anaphylatoxin, provokes acute inflammatory responses, including smooth muscle contraction, mucus hypersecretion, increase in vascular permeability, and recruitment of inflammatory cells. Thus C3a may be related to airway inflammation and bronchoconstriction in acute asthma exacerbation.We sought to determine whether plasma ...
Kingo Chida +2 more
exaly +3 more sources
Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia [PDF]
Hypertension, 2012 Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased complement activation in PE are largely unidentified ...
Rodney E Kellems +2 more
exaly +2 more sources
Preservation of antimicrobial properties of complement peptide C3a - from invertebrates to humans. [PDF]
Journal of Biological Chemistry, 2007 The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences ...
Walse, Bjorn +10 more
core +6 more sources
Nature Communications, 2017 Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and ...
Rink-Jan Lohman +13 more
doaj +2 more sources