Results 231 to 240 of about 49,845 (259)

The Role of Complement C3a Receptor in Stroke

NeuroMolecular Medicine, 2019
The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to the pathogenesis of a number of neurological diseases including stroke.
Andrew F. Ducruet, Adam Kindelin, Kanchan Bhatia, Kanchan Bhatia, Saif Ahmad   +4 more
openaire   +3 more sources

Complement fragment C3a in plasma of asphyxiated neonates

European Journal of Pediatrics, 1992
Recent clinical studies with adult polytrauma patients indicate that elevated plasma levels of anaphylatoxin C3a correlate with the subsequent development of the adult respiratory distress syndrome (ARDS). However, there are no parameters which allow a reliable diagnosis of ARDS in neonates. As the most predisposing condition for ARDS seems to be shock,
G. Frauendienst-Egger, L. Schrod, H. B. von Stockhausen, M. Kirschfink   +3 more
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ELISA of complement C3a in bronchoalveolar lavage fluid

Journal of Immunological Methods, 1992
Activated complement factors within the lung may induce several local biological effects. In order to investigate local complement activation we have developed non-competitive two-site ELISAs of C3a and total C3 in bronchoalveolar lavage fluid (BALF).
J. K. M. Eeftinck Schattenkerk, Marleen Bakker, Henk M. Jansen, E.A. van de Graaf, C. Alberts, Theo A. Out   +5 more
openaire   +3 more sources

Anti-analgesic and anti-amnesic effect of complement C3a

Life Sciences, 2000
In the present study, we found that complement C3a exerted central effects after intracerebroventricular administration in mice. At doses of 3 and 10 pmol/mouse, the peptide showed an antagonistic effect on analgesia induced by morphine and U-50488H, known to be mu- and kappa-opioid receptor agonists, respectively.
Masakazu Takahashi, Yunden Jinsmaa, Masaaki Yoshikawa, Masakatsu Takahashi   +3 more
openaire   +3 more sources

Potent Heterocyclic Ligands for Human Complement C3a Receptor

Journal of Medicinal Chemistry, 2014
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR antagonist (IC50 μM), was transformed here into potent agonists (EC50 nM) of human macrophages (Ca(2 ...
Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J., Fairlie, David P.   +6 more
openaire   +4 more sources

Albutensin A and complement C3a decrease food intake in mice

Peptides, 2002
Albutensin A (Ala-Phe-Lys-Ala-Trp-Ala-Val-Ala-Arg) derived from serum albumin dose-dependently decreased food intake after intracerebroventricular (10-50 nmol/mouse) or peripheral (0.3-1.0 micromol/mouse) administration in fasted conscious ddY mice. Albutensin A delayed gastric emptying and elevated blood glucose levels.
Masaaki Yoshikawa, Etsuko Wada, Keiji Wada, Akio Inui, Akihiro Asakawa, Kousaku Ohinata   +5 more
openaire   +3 more sources

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor

Journal of Medicinal Chemistry, 2010
Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled receptor, human C3aR. Previously reported short peptide ligands for this receptor either have low potency or lack receptor selectivity.
Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C., Fairlie, David P.   +6 more
openaire   +4 more sources

Complement C3a and C4a Increased in Plasma of Patients with Aspirin-induced Asthma [PDF]

American Journal of Respiratory and Critical Care Medicine, 2006
Aspirin-induced asthma (AIA) is a distinct clinical syndrome that affects up to 10% of adults with asthma. Although eicosanoid metabolites appear to play an important role in AIA, the exact pathogenic mechanism for the syndrome remains obscure. In addition, the proposed mechanism fails to explain why aspirin does not cause bronchoconstriction in all ...
Seung Ha Lee, Choon-Sik Park, Ji-Won Min, Tai Youn Rhim, Sung Ho Kim, Young Ki Paik, Sun Young Cho, Yun Sung Choi   +7 more
openaire   +2 more sources

Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis

Clinical Biochemistry, 2020
Endometriosis is a disease that shows auto-immune and chronic characteristics, suggesting a role for proteins mediating immune interactions in its pathophysiology. The aim was to evaluate C3a and C5a for their role in inflammatory responses and C6 as the down-stream interactor following our previous findings on C5 mRNA expression changes in ...
Hortu, Ismet, Karadadas, Elif, Ergenoglu, Ahmet Mete, Karadadas, Nedim, Aydin, Hikmet Hakan, Ak, Handan   +5 more
openaire   +4 more sources

Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways

Translational Research, 2006
Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other ...
Barbara A. Benson, Malcolm N. Blumenthal, Sven K. Wust, Edward O Corazalla, Agustin P. Dalmasso   +4 more
openaire   +3 more sources