Results 231 to 240 of about 27,207 (241)
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Molecular Immunology, 2014
Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are indispensable for T cell activation, stimulation of additional receptor pathways are also necessary for effector induction.
Ghannam +5 more
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Human T helper type 1 (Th1) responses are essential in defense. Although T cell receptor (TCR) and co-stimulator engagement are indispensable for T cell activation, stimulation of additional receptor pathways are also necessary for effector induction.
Ghannam +5 more
openaire +3 more sources
Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress
Molecular Neurobiology, 2015Astrocytes are the most numerous cells in the central nervous system with a range of homeostatic and regulatory functions. Under normal conditions as well as after ischemia, astrocytes promote neuronal survival. We have previously reported that the complement-derived peptide C3a stimulates neuronal differentiation of neural progenitor cells and ...
Shinjyo, Noriko +3 more
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Complement C3a predicts outcome in cardiac resynchronization therapy of heart failure
Inflammation Research, 2016The chronic inflammation plays an important role in heart failure and complement components might be useful markers of the prognosis. We set out to evaluate their predictive value in the clinical outcomes of patients with cardiac resynchronization therapy (CRT).We determined the complement levels C3, C3a, sC5b-9 and also the N-terminus of the ...
Széplaki, Gábor +13 more
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Complement peptide C3a inhibits IgEmediated triggering of rat mucosal mast cells
International Immunology, 1995The relationship between mast cells' secretory response to stimulation via their type 1 Fc epsilon receptors (Fc epsilon RI) and that provided by the C3a fragment of the complement system was investigated in the rat mucosal-type mast cell line RBL-2H3. These cells are known to be unresponsive to the so-called 'peptidergic' stimulus provided by cationic
A, Erdei, S, Andreev, I, Pecht
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Molecular Immunology, 2018
The complement system of innate immunity is emerging as a novel player in neurodevelopmental processes. The receptor for C3a, C3aR, shares a close evolutionary and functional relationship with C5a receptors. Whilst the C5a receptor, C5aR1, has been demonstrated to promote embryonic neural stem cell proliferation, little is known about the role of C3aR ...
Liam G. Coulthard +4 more
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The complement system of innate immunity is emerging as a novel player in neurodevelopmental processes. The receptor for C3a, C3aR, shares a close evolutionary and functional relationship with C5a receptors. Whilst the C5a receptor, C5aR1, has been demonstrated to promote embryonic neural stem cell proliferation, little is known about the role of C3aR ...
Liam G. Coulthard +4 more
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Complement C3a-C3aR signaling in the colon epithelium 4117
The Journal of ImmunologyAbstract Description The liver-derived complement system has been considered the body’s main source for the complement cascade. Recently, complement C3 was found to be expressed in the gut under steady-state conditions and during inflammatory conditions.
Jaclyn A. Rivas +4 more
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Complement C3a: Shaping the Plasticity of the Post-stroke Brain
2017Complement is part of the innate immune system that plays a major role in the initiation of inflammation and host defence against pathogenic bacteria. Complement activation is also a contributor to tissue damage in a range of autoimmune conditions. For those reasons, the activation of the complement system in the central nervous system (CNS) was for ...
Anna Stokowska, Marcela Pekna
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The Anaphylatoxic Peptide C3a of Guinea Pig Complement
Zeitschrift für Immunitätsforschung: Immunobiology, 1978Stefan Meuer +3 more
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Complement C3a levels and misinterpretation of classifier technology
Inflammation Research, 2016openaire +3 more sources
Characterization of a complement C3a receptor (C3aR) on astrocytes
Journal of Neuroimmunology, 1994A. Ischenko +6 more
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