Results 241 to 250 of about 49,845 (259)
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High Levels of Complement C3a Receptor in the Glomeruli in Lupus Nephritis
American Journal of Kidney Diseases, 2007Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states.Several antibodies were generated and used for immunohistochemistry and Western blot ...
Philippe Gasque +4 more
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Osteoclast differentiation and formation induced by titanium implantation through complement C3a
Materials Science and Engineering: C, 2021Titanium implantation is widely used for dental replacement with advantages of excellent mechanical strength, corrosion resistance, chemical stability and biocompatibility. Some patients, however, are subject to the failure of implantation due to bone resorption, which closely related to the inflammatory responses without clear mechanisms.
Siwen Li +9 more
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Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress
Molecular Neurobiology, 2015Astrocytes are the most numerous cells in the central nervous system with a range of homeostatic and regulatory functions. Under normal conditions as well as after ischemia, astrocytes promote neuronal survival. We have previously reported that the complement-derived peptide C3a stimulates neuronal differentiation of neural progenitor cells and ...
Yolanda de Pablo +7 more
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Induction of platelet aggregation by the complement-derived peptides C3a and C5a
Naunyn-Schmiedeberg's Archives of Pharmacology, 1976The effect of two complement-derived peptides, hog serum C3a and C5a, on platelet aggregation in platelet-rich plasma and suspensions in Tyrode solution was investigated. 1. Guinea-pig platelets were aggregated by both C3a and C5a; the spasmogenically inactive product of C3a, C3ai, also induced aggregation. Threshold concentrations were in the range of
Walther Vogt +3 more
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Complexes of IgG molecules and C3a and C4a complement components in human serum [PDF]
European Journal of Immunology, 1992 AbstractA heterogeneous group of proteins was separated from human serum IgG using 5 M guanidine hydrochloride solution in 0.1 M acetic acid. The protein mixture was fractionated by reverse‐phase high‐performance liquid chromatography and two proteins were isolated and identified as the C3a and C4a complement components (anaphylatoxins) according to ...
Roald Nezlin, Andrew Freywald
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Molecular Immunology, 1980
Dose-response experiments with guinea pig C3a and a synthetic hexapeptide (amino acid residues 72–77), representing the COOH-terminal sequence of human C3a, were performed in two recently described bioassay systems for C3a, i.e. cytotoxicity against tumor cells measured as LDH and 51Cr-release and non cytolytic serotonin release from guinea pig ...
S. Becker +5 more
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Dose-response experiments with guinea pig C3a and a synthetic hexapeptide (amino acid residues 72–77), representing the COOH-terminal sequence of human C3a, were performed in two recently described bioassay systems for C3a, i.e. cytotoxicity against tumor cells measured as LDH and 51Cr-release and non cytolytic serotonin release from guinea pig ...
S. Becker +5 more
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Complement C3a: Shaping the Plasticity of the Post-stroke Brain
2017Complement is part of the innate immune system that plays a major role in the initiation of inflammation and host defence against pathogenic bacteria. Complement activation is also a contributor to tissue damage in a range of autoimmune conditions. For those reasons, the activation of the complement system in the central nervous system (CNS) was for ...
Marcela Pekna, Anna Stokowska
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Complement anaphylatoxin C3a and C5a formation in premature children with respiratory distress
European Journal of Pediatrics, 1996Premature children (n = 25) with respiratory distress (RD) were studied regarding complement activation and formation of the anaphylatoxins C3a and C5a. Blood samples were drawn on admission to the paediatric intensive care unit. In 18 of the patients RD was accompanied by other perinatal complications like pneumothorax or intracerebral haemorrhages ...
J. P. Bengtson +5 more
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Forensic Science International, 1992
The anaphylatoxin C3a or its desArg form (C3a/desArg) generated during complement activation could be detected in the vicinity of incised skin wounds of guinea pigs using immunoblotting methods. The C3a/desArg peptides were detectable immediately after injury in local sites up to 3 mm from the wound edge.
Fukutaro Takabe +4 more
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The anaphylatoxin C3a or its desArg form (C3a/desArg) generated during complement activation could be detected in the vicinity of incised skin wounds of guinea pigs using immunoblotting methods. The C3a/desArg peptides were detectable immediately after injury in local sites up to 3 mm from the wound edge.
Fukutaro Takabe +4 more
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Complement fragments C3a and C5a: The salt and pepper of the immune response
European Journal of Immunology, 2010AbstractThe influence of complement on B‐cell responses has been known for many years, but the notion that T‐cell recognition, expansion and differentiation are complement dependent has only recently gained impetus. DC, and to a lesser extent T cells, produce a range of complement components necessary for complement activation, and these cells also ...
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