Results 21 to 30 of about 27,207 (241)

The Complex Role of the Complement C3a Receptor (C3aR) in Cerebral Injury and Recovery Following Ischemic Stroke. [PDF]

Cells
Akhter N, Lambay A, Almotairi R, Hamadi A, Bhatia K, Ahmad S, Ducruet AF.   +6 more
europepmc   +3 more sources

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy.

J Am Soc Nephrol, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Gao S, Cui Z, Zhao MH.
europepmc   +3 more sources

Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway. [PDF]

Neurosci Bull
Ding L, Li X, Guo Y, Zhou FQ, Deng DYB.
europepmc   +3 more sources

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury. [PDF]

Neurochem Res, 2021
AbstractIschemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke is due to cell death in the infarcted tissue, cell dysfunction in the peri-infarct region, as well as dysfunction and ...
Pekna M, Stokowska A, Pekny M.
europepmc   +4 more sources

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant. [PDF]

Am J Transplant, 2018
Cheng Q, Patel K, Lei B, Rucker L, Allen DP, Zhu P, Vasu C, Martins PN, Goddard M, Nadig SN, Atkinson C.   +10 more
europepmc   +3 more sources

Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma

BMC Psychiatry, 2022
Background Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mechanism of immune activation.
Xianmei Luo, Zeman Fang, Lingyun Lin, Haiyun Xu, Qingjun Huang, Handi Zhang   +5 more
doaj   +1 more source

Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]

PLoS ONE, 2012
The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet, Brad E Zacharia, Sergey A Sosunov, Paul R Gigante, Mason L Yeh, Justin W Gorski, Marc L Otten, Richard Y Hwang, Peter A DeRosa, Zachary L Hickman, Paulina Sergot, E Sander Connolly   +11 more
doaj   +1 more source

Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism

Frontiers in Immunology, 2021
Complement component 3 fragment C3a is an anaphylatoxin involved in promoting cellular responses important in immune response and host defense. Its receptor (C3a receptor, C3aR) is distributed on the plasma membrane; however, lysosomal localization in ...
Masaaki Ishii, Gyda Beeson, Craig Beeson, Bärbel Rohrer, Bärbel Rohrer, Bärbel Rohrer   +5 more
doaj   +1 more source