Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]
, 2011 BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A +5 more
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Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury [PDF]
, 2010 Objective: Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury.
Busche, Marc N., Stahl, Gregory L.
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Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]
, 1993 Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin +8 more
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The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
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Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds. [PDF]
, 2008 The complement C3a anaphylatoxin is a major molecular mediator of innate immunity. It is a potent activator of mast cells, basophils and eosinophils and causes smooth muscle contraction.
Chang, Jui-Yoa +4 more
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Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis. [PDF]
Levels of activated complement proteins in the CSF are increased in people with multiple sclerosis (MS) and are associated with clinical disease severity.
Achtnichts, L. +37 more
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Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
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Acidosis activates complement system in vitro. [PDF]
, 1998 We investigated the in vitro effect of different forms of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 micromol/ml blood) or lactic acid (5.5 micromol/ml) to heparin blood ...
Emeis, M +5 more
core +3 more sources
Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]
, 2015 Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO +3 more
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Determination of Anaphylatoxin Concentrations in Suction Blisters in Patients with Psoriasis [PDF]
, 1986 Concentrations of C3a and C4a anaphylatoxins in suction blister fluids were determined by radioimmunoassay in patients with psoriasis and normal controls.
Ohkohchi, Kyoto +2 more
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