Results 31 to 40 of about 36,864 (64)
Quantifying "just-right" APC inactivation for colorectal cancer initiation [PDF]
arXivDysregulation of the tumour suppressor gene Adenomatous Polyposis Coli (APC) is a canonical step in colorectal cancer development. Curiously, most colorectal tumours carry biallelic mutations that result in only partial loss of APC function, suggesting that a "just-right" level of APC inactivation, and hence Wnt signalling, provides the optimal ...
arxiv
Circadian Clock Model with Sequestration Repression Motif: Existence of Periodic Orbits and Entrainment Properties [PDF]
arXivProtein sequestration motifs appear in many biological regulatory networks and introduce special properties into the network dynamics. Sequestration can be described as a mode of inactivation of a given protein by its binding to a second protein to form a new complex.
arxiv
Conserved network motifs allow protein-protein interaction prediction [PDF]
arXiv, 2004 High-throughput protein interaction detection methods are strongly affected by false positive and false negative results. Focused experiments are needed to complement the large-scale methods by validating previously detected interactions but it is often difficult to decide which proteins to probe as interaction partners.
arxiv
Spatial organization of proteomes: A low-rank approximation [PDF]
arXiv, 2012 We investigate the problem of signal transduction via a descriptive analysis of the spatial organization of the complement of proteins exerting a certain function within a cellular compartment. We propose a scheme to assign a numerical value to individual proteins in a protein interaction network by means of a simple optimization algorithm. We test our
arxiv
Rate equations for a Na+ channel gating master equation during the action potential within a neural membrane [PDF]
arXiv, 2017 The action potential in a neural membrane is generated by Na+ and K+ channel ionic currents that may be calculated from a current equation and the rate equations for activation variables m and n, and the Na+ inactivation variable h. Assuming that a Na+ channel has three activation sensors, and activation and inactivation are cooperative processes, a ...
arxiv
Realistic protein-protein association rates from a simple diffusional model neglecting long-range interactions, free energy barriers, and landscape ruggedness [PDF]
Protein Science (13), 1660-1669 (2004), 2004 We develop a simple but rigorous model of protein-protein association kinetics based on diffusional association on free energy landscapes obtained by sampling configurations within and surrounding the native complex binding funnels. Guided by results obtained on exactly solvable model problems, we transform the problem of diffusion in a potential into ...
arxiv
Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]
arXivThe intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv
The Journal of Biochemistry, 1985 Limited proteolysis of C3b by C3b inactivator (factor I) consists of a two-step reaction; rapid cleavage of C3b to yield a nicked C3b derivative, iC3b, and followed by slow cleavage of iC3b to yield two antigenically distinct fragments, C3c and C3d,g.
Tsukasa Seya, Shigeharu Nagasawa
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Journal of Immunological Methods, 1984 Factor H, purified from mouse EDTA-plasma using a 4-step procedure, consists of a single polypeptide chain of Mr 150,000 on SDS-PAGE. Mouse H (Hmo) was required for the cleavage of fluid-phase mouse C3b by mouse I (Imo). The final product of degradation of fluid-phase mouse C3b was iC3b, consisting of fragments of the alpha'-chain (alpha'-70, alpha'-43)
Taroh Kinoshita, Victor Nussenzweig
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