Alternative Complement Pathway Inhibition by Lampalizumab
Ophthalmology Science, 2023 Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration.
Rose Edmonds, MS +3 more
doaj
Plasma proteome changes associated with refractory cytopenia with multilineage dysplasia
Proteome Science, 2011 Background Refractory cytopenia with multilineage dysplasia (RCMD) is a subgroup of myelodysplastic syndrome (MDS), which belongs to oncohematological diseases, occurring particularly in elderly patients, and represents a heterogeneous group of bone ...
Čermák Jaroslav +4 more
doaj +1 more source
C-Reactive Protein Levels Are Associated with Complement C4 Deposits and Interstitial Arteritis in ANCA-Associated Renal Vasculitis. [PDF]
Int J Mol Sci, 2023 Korsten P, Baier E, Hakroush S, Tampe B.
europepmc +1 more source
Anticomplementary activity of Fusobacterium polymorphum in normal and C4-deficient sources of guinea pig complement [PDF]
, 1977 Charles E. Hawley, William A. Falkler
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Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
Advanced Science, EarlyView.This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang +16 more
wiley +1 more source
Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q. [PDF]
, 1988 C Bindon +3 more
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Advanced Science, EarlyView.BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI) and brain–body interaction research. It supports electroencephalography (EEG), functional near‐infrared spectroscopy (fNIRS), electromyography (EMG), and electrocardiography (ECG) integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li +10 more
wiley +1 more source
Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. [PDF]
J Trauma Acute Care Surg, 2022 Schaid TR +14 more
europepmc +1 more source
Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4. [PDF]
, 1985 Lars Sottrup‐Jensen +9 more
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Regulation of B-cell tolerance by complement C4
Arthritis Research & Therapy, 2004 Systemic lupus erythematosus (SLE) is a B-cell-dependent autoimmune disease characterized by autoantibodies specific for nuclear antigens such as dsDNA and histones. Apoptotic blebs released from dying cells are thought to represent a major source of autoantigen.
Marat Alimzhanov +2 more
openaire +2 more sources