Results 151 to 160 of about 905,894 (352)

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma. [PDF]

Front Endocrinol (Lausanne), 2021
Wang Y, Zhou S, Wang D, Wei T, Zhu J, Li Z.   +5 more
europepmc   +1 more source

Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes

bioRxiv, 2020
M. Druart, M. Nosten-Bertrand, Stefanie Poll, Sophie Crux, F. Nebeling, Célia Delhaye, Yaëlle Dubois, M. Mittag, M. Leboyer, R. Tamouza, Martin Fuhrmann, C. Le Magueresse   +11 more
semanticscholar   +1 more source

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker‐Based Drug Screening for Neurodegenerative Diseases

Advanced Science, EarlyView.
This work introduces an on‐chip, integrated plasmonic infrared microarray sensor that enables high‐throughput, label‐free drug screening targeting structural protein biomarkers in neurodegenerative diseases. Through ultra‐compact microwell arrays, the sensor achieves ultra‐sensitive, rapid, and multiplexed secondary structural analysis of the effect of
Deepthy Kavungal, Enzo Morro, Senthil T Kumar, Berkay Dagli, Hilal A Lashuel, Hatice Altug   +5 more
wiley   +1 more source

Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion. [PDF]

Clin Proteomics, 2022
Sun X, Jin J, Zhang YL, Ma Y, Zhang S, Tong X.   +5 more
europepmc   +1 more source

Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig. [PDF]

, 1983
Alexander S. Whitehead, Gabriel Goldberger, D E Woods, Alexander F. Markham, Harvey R. Colten   +4 more
openalex   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA. [PDF]

, 1984
R T Ogata, Diane S. Sepich
openalex   +1 more source

Beyond Planar: Enhanced Performance of Hollow Fiber Dielectric Elastomer Actuators

Advanced Science, EarlyView.
This study presents a comprehensive analysis of hollow fiber dielectric elastomer actuators, highlighting their superior strain performance compared to planar actuators. By combining analytical modeling, numerical simulations, and experiments, it identifies optimal fiber geometries that maximize actuation efficiency.
Sina Jafarzadeh, Anne Ladegaard Skov
wiley   +1 more source

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes. [PDF]

Front Cell Neurosci, 2023
Veremeyko T, Jiang R, He M, Ponomarev ED.   +3 more
europepmc   +1 more source