Results 201 to 210 of about 942,109 (243)

Complement C4 and Autoimmune Diseases

The Journal of Immunology
Complement activation on autologous cells causes tissue injuries but the process is not well studied. We seek to elucidate how C4 variants, their activation products and isotype deficiencies contribute to increased risks of children systemic lupus ...
Danlei Zhou, Samantha L. Coss, Rabheh Abdul Aziz, Joanne Drew, Katherine Miller, K. Driest, V. Sivaraman, Charles Spencer, Fatima Barbar-Smiley, S. Ardoin, Chack-Yung Yu   +10 more
semanticscholar   +2 more sources

Complete Deficiency of Complement C4

Encyclopedia of Medical Immunology, 2020
K. Mayilyan, Armenuhi A. Hyusyan, Jack Farah   +2 more
semanticscholar   +2 more sources

Complement C4, the Major Histocompatibility Complex, and Autoimmunity

Arthritis & Rheumatology, 2022
For many autoimmune diseases, including systemic lupus erythematosus (SLE) and primary Sjögren ’ s syndrome (SS), genome-wide association analyses (GWAS) reveal that the major histocompatibility complex (MHC) is the site of the stron-gest genetic ...
T. Vyse, B. Tsao
semanticscholar   +1 more source

Complement Factor C4 in Schizophrenia

Human Heredity, 1985
The complement factor C4 was studied in 165 schizophrenic patients and in 330 controls. A highly significant increase in the frequency of C4B deficiency (BQO) was found among the schizophrenic patients compared with controls (p less than 0.0005).
C, Rudduck, L, Beckman, G, Franzén, L, Jacobsson, L, Lindström   +4 more
openaire   +2 more sources

Polymorphism of human complement component C4

Immunogenetics, 1985
An assessment has been made of the polymorphism of human complement component C4 by comparing derived amino acid sequences of cDNA and genomic DNA with limited amino acid sequences. In all, one complete and six partial sequences have been obtained from material from three individuals and include two C4A and two C4B alleles.
K T, Belt, C Y, Yu, M C, Carroll, R R, Porter   +3 more
openaire   +2 more sources

C4 complement allotypes in juvenile dermatomyositis

Human Immunology, 1988
Twenty probands with juvenile dermatomyositis and their relatives were studied to determine the inherited segregation patterns of class I, II, and III HLA region markers including C4A, C4B, Bf, and C2 complement polymorphisms. The extended haplotype B8, DR3, C4A*Q0, C4B*1, C2*C, and Bf*S was present in 13 of the 20 probands.
S A, Robb, A H, Fielder, C E, Saunders, N J, Davey, M W, Burley, D H, Lord, J R, Batchelor, V, Dubowitz   +7 more
openaire   +2 more sources

Genetic studies of complement C4 in man

Human Genetics, 1979
A C4 variant found in about 5% of the population is described. The fast-moving part of this variant is governed by an allele (Fx) codominant to F. The Fx allele is in very strong linkage disequilibrium with HLA-B17 as the linkage disequilibrium parameter accounted for nearly 100% of the haplotype frequency of B17,Fx.
G B, Petersen, I J, Sørensen, L, Buskjaer, L U, Lamm   +3 more
openaire   +2 more sources

Complement components (C3, C4) in childhood asthma

The Indian Journal of Pediatrics, 2005
To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma. Serum levels of complement components (C3, C4) were measured by radial immunodiffusion technique in 64 Libyan children (age:
F I E, Najam, A S M, Giasuddin, A H, Shembesh   +2 more
openaire   +2 more sources