Results 201 to 210 of about 49,973 (249)

Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

Human Genetics, 1982
A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather ...
G, Bruun-Petersen, L U, Lamm, B K, Jacobsen, T, Kristensen   +3 more
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Sex, MHC and complement C4 in autoimmune diseases

Trends in Immunology, 2004
Autoimmune diseases are estimated to affect 10-50 million people in the United States, and untold millions worldwide. Nearly 80% of all people with autoimmune diseases are women, and a strong association of these diseases with MHC genes has been known for some time. However, very little is known about what causes autoimmune diseases or the factors that
C Yung, Yu, Caroline C, Whitacre
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C4A7: A New Variant of Human Complement C4

Human Heredity, 1988
A rare variant of complement C4 was found in 2 related individuals. It has the most anodic mobility found to date, no hemolytic activity detected by the overlay technique and a Bgl II RFLP pattern very similar to that of the C4A6 type.
M, Abbal, F, de Paoli, M, Cuccia-Belvedere, M, Martinetti   +3 more
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Complement components (C3, C4) in childhood asthma

The Indian Journal of Pediatrics, 2005
To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma. Serum levels of complement components (C3, C4) were measured by radial immunodiffusion technique in 64 Libyan children (age:
F I E, Najam, A S M, Giasuddin, A H, Shembesh   +2 more
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The effect of null C4 alleles on complement function

Clinical Immunology and Immunopathology, 1985
C4 is encoded at two polymorphic genetic loci (C4A and B), and "null" or unexpressed alleles are relatively common. An increased frequency of nulls has been reported in a variety of diseases. In the present study, C4 allotypes and C4 hemolytic efficiencies (the ratios of functional to antigenic levels) were determined for a population of 75 normal ...
T R, Welch, L, Beischel, A, Berry, J, Forristal, C D, West   +4 more
openaire   +2 more sources

Complement C4 and Autoimmune Diseases

The Journal of Immunology
Abstract Complement activation on autologous cells causes tissue injuries but the process is not well studied. We seek to elucidate how C4 variants, their activation products and isotype deficiencies contribute to increased risks of children systemic lupus erythematous (cSLE) and juvenile dermatomyositis (JDM).
Danlei Zhou, Samantha Coss, Rabheh Abdul Aziz, Joanne Drew, Katherine Miller, Kyla Driest, Vidya Sivaraman, Charles Spencer, Fatima Barbar-Smiley, Stacy P Ardoin, Chack-Yung Yu   +10 more
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Interaction of nucleophilic compounds with complement component C4

Comparative Immunology, Microbiology and Infectious Diseases, 1988
Drugs which induce systemic lupus erythematosus as a toxic side effect have been shown to inhibit the covalent binding of C4, which is an important event in immune complex clearance in normal individuals. Human C4 is encoded at two polymorphic loci, C4A and C4B within the Major Histocompatibility Complex and patients with idiopathic SLE are more likely
E, Sim, M, Wood, K E, Parker, A, Jones
openaire   +2 more sources

Complement Components, C3 and C4, and the Metabolic Syndrome

Current Diabetes Reviews, 2018
Introduction: Increased systemic inflammation plays a significant role in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. The complement system is a part of the innate immune system and plays a key role in the regulation of inflammation.
Melanie, Copenhaver, Chack-Yung, Yu, Robert P, Hoffman   +2 more
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Isolation of the Fourth Component (C4) of Rat Complement

The Journal of Immunology, 1979
Abstract The fourth component of rat complement was purified to homogeneity by sequential chromatography of rat plasma in benzamidine on QAE-A50, SP-C50, hydroxyapatite, and gel filtration on Bio-Gel A 1.5. The final material was homogeneous on SDS-PAGE analysis and had a calculated m.w. of 198,000. A monospecific antibody against rat C4
M R, Daha, L A, van ES
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The complement component C4 in sudden infant death

European Journal of Pediatrics, 1999
The aim of the present study was to compare partial deletions of the complement C4 gene in victims of totally unexplained sudden infant death (SID) (n = 89) and borderline SID (n = 15) with and without slight infections prior to death, in cases of infectious death (n = 19), and in living infants with and without infections (n = 84).
S H, Opdal, A, Vege, A K, Stave, T O, Rognum   +3 more
openaire   +2 more sources