Results 311 to 320 of about 905,894 (352)

Polymorphism of human complement component C4

Immunogenetics, 1985
An assessment has been made of the polymorphism of human complement component C4 by comparing derived amino acid sequences of cDNA and genomic DNA with limited amino acid sequences. In all, one complete and six partial sequences have been obtained from material from three individuals and include two C4A and two C4B alleles.
K. Tertia Belt, Michael C. Carroll, Rodney R. Porter, C. Yung Yu   +3 more
openaire   +3 more sources

C4 complement allotypes in juvenile dermatomyositis

Human Immunology, 1988
Twenty probands with juvenile dermatomyositis and their relatives were studied to determine the inherited segregation patterns of class I, II, and III HLA region markers including C4A, C4B, Bf, and C2 complement polymorphisms. The extended haplotype B8, DR3, C4A*Q0, C4B*1, C2*C, and Bf*S was present in 13 of the 20 probands.
M.W. Burley, A.H.L. Fielder, V. Dubowitz, S.A. Robb, D.H. Lord, Nick Davey, C.E. Saunders, J. R. Batchelor   +7 more
openaire   +3 more sources

Genetic studies of complement C4 in man

Human Genetics, 1979
A C4 variant found in about 5% of the population is described. The fast-moving part of this variant is governed by an allele (Fx) codominant to F. The Fx allele is in very strong linkage disequilibrium with HLA-B17 as the linkage disequilibrium parameter accounted for nearly 100% of the haplotype frequency of B17,Fx.
G. B. Petersen, Inger Juncker Sørensen, L. U. Lamm, Lisbeth Buskjaer   +3 more
openaire   +3 more sources

Genetic polymorphism of complement C4 in the dog

Tissue Antigens, 1984
Plasma samples from 129 dogs have been typed using an immunofixation technique to define the polymorphism of canine C4. The mode of inheritance was inferred by study of four large pedigrees. In contrast to the situation in man, canine C4 may be encoded by a single locus. At least five different co‐dominant structural alleles have been detected.
Roger L. Dawkins, P H Kay
openaire   +3 more sources

Complement C4 and Autoimmune Diseases

Journal of Immunology
Complement activation on autologous cells causes tissue injuries but the process is not well studied. We seek to elucidate how C4 variants, their activation products and isotype deficiencies contribute to increased risks of children systemic lupus ...
Danlei Zhou, Samantha L. Coss, Rabheh Abdul Aziz, Joanne Drew, Katherine Miller, K. Driest, V. Sivaraman, Charles Spencer, Fatima Barbar-Smiley, S. Ardoin, Chack-Yung Yu   +10 more
semanticscholar   +1 more source

Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

Human Genetics, 1982
A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather ...
Bodil K. Jacobsen, L. U. Lamm, G. Bruun-Petersen, Tom Kristensen   +3 more
openaire   +3 more sources

Detection of complement C4 with a piezoelectric immunosensor

Chinese Journal of Chemistry, 1998
AbstractA piezoelectric immunosensor has been developed for the detection of complement C4. Anti‐C4 antibody was immobilized onto the gold electrodes of a 9 MHz AT‐cut piezoelectric crystal. The coated crystal with the physical adsorption method to immobilize antibody showed the better results than the polyethyleneimine adhesion, glutaraldehyde cross ...
Zeng Yun'e, Pei Renjun, Hu Yi, Hu Jiming
openaire   +2 more sources

C4A7: A New Variant of Human Complement C4

Human Heredity, 1988
A rare variant of complement C4 was found in 2 related individuals. It has the most anodic mobility found to date, no hemolytic activity detected by the overlay technique and a Bgl II RFLP pattern very similar to that of the C4A6 type.
F. De Paoli, M. Abbal, M. Cuccia-Belvedere, Miryam Martinetti   +3 more
openaire   +3 more sources

Serum complement C4 in chronic hepatitis C: correlation with histopathologic findings and disease activity.

The Turkish Journal of Gastroenterology, 2012
BACKGROUND/AIMS Hepatitis C virus leads to chronic liver disease, cirrhosis and hepatocellular cancer. Viral markers and other laboratory tests used in the diagnosis and follow-up of chronic hepatitis C do not correlate well with disease activity and ...
M. S. Buğdacı, Ç. Karaca, C. Alkim, B. Kesici, B. Bayraktar, Mehmet H Sökmen   +5 more
semanticscholar   +1 more source

Sex, MHC and complement C4 in autoimmune diseases

Trends in Immunology, 2004
Autoimmune diseases are estimated to affect 10-50 million people in the United States, and untold millions worldwide. Nearly 80% of all people with autoimmune diseases are women, and a strong association of these diseases with MHC genes has been known for some time. However, very little is known about what causes autoimmune diseases or the factors that
Caroline C. Whitacre, C. Yung Yu
openaire   +3 more sources